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基于DTP药房回访数据探讨利司扑兰相关药学服务价值
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| 篇名： | 基于DTP药房回访数据探讨利司扑兰相关药学服务价值 |
| TITLE： | Study on the value of pharmaceutical service related to risdiplam based on follow-up data of DTP pharmacy |
| 摘要： | 目的 探索直销患者（DTP）药房开展利司扑兰相关药学服务的价值。方法收集2021年5月－2023年1月在上药云健康益药药房（上海）有限公司购买并使用利司扑兰的脊髓性肌萎缩症（SMA）患者的随访数据，对患者用药情况、药物治疗效果、不良事件发生情况进行回顾性分析。结果DTP药房药师共审核处方42份，发现不合理处方7份（16.7%，7/42），经药师及时干预后纠正。随访过程中，药师对4例（9.5%，4/42）患者关于利司扑兰服药要求、用药后不良事件等用药咨询进行专业解答。2例1型SMA患者出现不良事件：其中1例表现为发热，1例表现为皮肤干燥、局部颜色变暗；两者为Ⅰ级毒性反应，一般无需临床治疗，但考虑发热患者长时间持续低热，药师建议就医对症处理。结论DTP药房药师开展罕见病SMA患者使用利司扑兰的随访管理有助于促进患者合理规范用药。 |
| ABSTRACT： | OBJECTIVE To explore the value of providing pharmaceutical service related to risdiplam in direct-to-patient （DTP） pharmacies. METHODS The follow-up data of spinal muscular atrophy （SMA） patients who purchased and used risdiplam from Shangyao Yunjiankang Yiyao Pharmacy （Shanghai） Co.， Ltd. from May 2021 to January 2023 were collected. The medication information， therapeutic efficacy and the occurrence of adverse events were retrospectively analyzed. RESULTS A total of 42 prescriptions were checked by pharmacists in the DTP pharmacies， and 7 prescriptions were found to be unreasonable （16.7%， 7/42）， which were corrected after the timely intervention. During the follow-up management， pharmacists replied to 4 patients （9.5%， 4/42） regarding medication consultation about medication requirements and adverse events. Two patients with type Ⅰ SMA experienced adverse events： one of them presented with fever and the other presented with skin dryness with darkening. Both of them were grade Ⅰ toxic reactions and generally did not require clinical treatment. Considering that the patient sustained low-grade fever for a long time， the pharmacist suggested symptomatic treatment under the guidance of the doctor. CONCLUSIONS Pharmacists in DTP pharmacies conducting follow-up management of risdiplam use for rare disease SMA patients can help promote rational， standardized medication for patients. |
| 期刊： | 2023年第34卷第19期 |
| 作者： | 石再欢；王芳婷；郭芷君；黄硕涵；朱林蕙；王喆元；杜琼；翟青 |
| AUTHORS： | SHI Zaihuan， WANG Fangting，GUO Zhijun，HUANG Shuohan，ZHU Linhui，WANG Zheyuan，DU Qiong，ZHAI Qing |
| 关键字： | DTP药房；药学服务；脊髓性肌萎缩症；利司扑兰；罕见病 |
| KEYWORDS： | DTP pharmacy； pharmaceutical service； spinal muscular atrophy； risdiplam； rare diseases |
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