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苦参-黄柏药对的提取工艺研究
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| 篇名： | 苦参-黄柏药对的提取工艺研究 |
| TITLE： | Study on extraction technology of Sophora flavescens-Phellodendron chinense drug pair |
| 摘要： | 目的 研究苦参-黄柏药对的提取工艺，为治疗肛肠疾病的新药开发提供参考依据。方法以苦参总碱（苦参碱+氧化苦参碱）含量、盐酸小檗碱含量、总黄酮含量及浸膏得率为评价指标，采用层次分析法-熵权法计算各指标权重系数，结合Box-Behnken设计-响应面法研究苦参-黄柏药对的最佳提取工艺并进行验证。结果苦参-黄柏药对的最优提取工艺为以12倍量58%乙醇浸泡30min后提取2次，每次120min。验证实验结果与预测值的相对误差为1.88%。结论所得提取工艺稳定、可行，可为苦参-黄柏药对的进一步应用与新药开发提供参考。 |
| ABSTRACT： | OBJECTIVE To study the extraction technology of Sophora flavescens-Phellodendron chinense drug pair and provide a reference for the development of new drugs for the treatment of anorectal diseases. METHODS Using the contents of total alkaloids of S. flavescens （matrine+oxymatrine）， berberine hydrochloride and total flavonoid， and extract yield as evaluation indicators， analytic hierarchy process-entropy weight method was used to calculate the weight coefficient of each indicator， and was combined with Box-Behnken design-response surface method to study the extraction technology of S. flavescens-P. chinense drug pair and verify it. RESULTS The optimal extraction technology of S. flavescens-P. chinense drug pair was immersed in 12-fold amount of 58% ethanol for 30 minutes and extracted twice， each time for 120 minutes. The relative error between the verification experimental results and the predicted value was 1.88%. CONCLUSIONS The obtained extraction technology is stable and feasible and can provide reference for the application of S. flavescens-P. chinense drug pair and development of new drugs. |
| 期刊： | 2024年第35卷第07期 |
| 作者： | 管咏梅；陶颖；邹成玉；臧振中；陈丽华；刘丽丽；陈丽梅；朱卫丰 |
| AUTHORS： | GUAN Yongmei，TAO Ying，ZOU Chengyu，ZANG Zhenzhong，CHEN Lihua，LIU Lili，CHEN Limei，ZHU Weifeng |
| 关键字： | 苦参；黄柏；药对；Box-Behnken设计；响应面法；提取工艺；层次分析法；熵权法；痔疮 |
| KEYWORDS： | Sophora flavescens； Phellodendron chinense； drug pair； Box-Behnken design； response surface method； |
| 阅读数： | 46 次 |
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