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中药调控p53信号通路干预肺癌的作用机制研究进展
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| 篇名： | 中药调控p53信号通路干预肺癌的作用机制研究进展 |
| TITLE： | Mechanism research progress of traditional Chinese medicine intervening in lung cancer by regulating p53 signaling pathway |
| 摘要： | 肺癌是最常见的恶性肿瘤，其发病机制复杂、恶性程度高，严重威胁了患者的生命健康。p53信号通路是影响肺癌进程的重要通路，被众多研究者视为肺癌靶向治疗的潜在靶点之一。近年来，已有较多研究深入探讨了中药调控p53信号通路干预肺癌的可行性。基于此，本文系统总结了中药调控p53信号通路干预肺癌的作用机制研究进展，发现清金得生片、调气消积汤、补肺通络解毒方、健脾补肾方及益气扶正解毒方等中药复方及制剂可通过激活p53信号通路，促进肺癌细胞自噬及凋亡，抑制肺癌细胞生长及转移，增强机体免疫功能，发挥抑癌作用；拟人参皂苷Rh2、柴胡皂苷D、重楼皂苷Ⅶ、石斛碱、槐定碱、藤黄酸、雷公藤甲素及雷公藤甲素丁二酸单酯YJ-4等中药单体可通过激活p53信号通路，促进肺癌细胞凋亡，抑制肺癌细胞增殖，调控肺癌细胞周期，发挥抑癌作用。 |
| ABSTRACT： | Lung cancer， the most common malignant tumor， is characterized by a complex pathogenesis and high malignancy， and poses a significant threat to the health and lives of affected individuals. p53 signaling pathway plays a crucial role in the progression of lung cancer and is considered one of the potential targets for targeted therapy. In recent years， multiple studies have indicated that traditional Chinese medicine （TCM） can exert anticancer effects by modulating the p53 signaling pathway. Based on this， this article systematically summarizes the current status and progress of research on TCM intervening in lung cancer by regulating p53 signaling pathway. It was found that TCM formula and preparations， such as Qingjin desheng tablet， Tiaoqi xiaoji decoction， Bufei tongluo jiedu formula， Jianpi bushen formula and Yiqi fuzheng jiedu formula， can promote autophagy and apoptosis of lung cancer cells， inhibit the growth and metastasis of lung cancer cells and strengthen the immune function of the body by activating p53 signaling pathway， thereby inhibiting lung cancer. TCM monomers， such as pseudoginsenoside-Rh2， saikosaponin D， polyphyllin Ⅶ， dendrobiine， sophoridine， gambogic acid， triptolide and triptolide succinate monoester YJ-4， can accelerate cell apoptosis， inhibit the proliferation of lung cancer cells and regulate cell cycle by activating p53 signaling pathway， thereby inhibiting lung cancer. |
| 期刊： | 2024年第35卷第11期 |
| 作者： | 马倩；李亚；马艺钊；陈锴；王元元；张海龙 |
| AUTHORS： | MA Qian，LI Ya，MA Yizhao，CHEN Kai，WANG Yuanyuan，ZHANG Hailong |
| 关键字： | 肺癌；p53信号通路；作用机制；中药；有效成分 |
| KEYWORDS： | lung cancer； p53 signaling pathway； mechanism； traditional Chinese medicine； effective components |
| 阅读数： | 38 次 |
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