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卡瑞利珠单抗联合索拉非尼治疗晚期肝癌的临床观察
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| 篇名： | 卡瑞利珠单抗联合索拉非尼治疗晚期肝癌的临床观察 |
| TITLE： | Clinical observation of camrelizumab combined with sorafenib in the treatment of advanced liver cancer |
| 摘要： | 目的 观察卡瑞利珠单抗联合索拉非尼治疗晚期肝癌的临床疗效和安全性。方法选择我院2020年3月－2021年11月收治的60例晚期肝癌患者，将其按随机数字表法分为研究组和对照组，每组各30例。对照组患者给予甲苯磺酸索拉非尼片（0.4g，bid，口服），研究组患者在对照组用药的基础上给予注射用卡瑞利珠单抗（200mg，每3周1次，静脉滴注），所有患者均治疗至疾病进展或发生不可耐受的副反应时停止治疗。比较两组患者的临床疗效、无进展生存期（PFS）、总生存期（OS）、1年生存率，记录两组患者治疗期间的不良反应及研究组患者的免疫相关不良事件发生情况。结果研究组患者的客观缓解率显著高于对照组（36.7%vs13.3%，P＜0.05），中位OS和中位PFS均显著长于对照组（OS：12.6个月vs7.9个月；PFS：8.2个月vs5.3个月，P＜0.05）。两组患者的1年生存率及天冬氨酸转氨酶和丙氨酸转氨酶升高、皮疹或皮肤瘙痒、食欲减退、腹泻、乏力、高血压发生率比较，差异均无统计学意义（P＞0.05）。研究组患者发生的免疫治疗相关不良事件主要包括反应性毛细血管增生症21例（70.0%）、甲状腺功能减退6例（20.0%）、免疫相关性肺炎1例（3.3%），经对症治疗后均有所好转或可耐受。结论卡瑞利珠单抗联合索拉非尼可有效控制和延缓晚期肝癌患者的病情进展，延长患者生存时间，且不良反应可耐受。 |
| ABSTRACT： | OBJECTIVE To observe the clinical efficacy and safety of camrelizumab combined with sorafenib in the treatment of advanced liver cancer. METHODS Sixty patients with advanced liver cancer who were treated in our hospital from March 2020 to November 2021 were selected as the study subjects， and then were randomly divided into study group and control group， with 30 cases in each group. The control group was treated with Sorafenib tosylate tablets orally （0.4 g，bid）， and the study group was additionally given Camrelizumab for injection intravenously （200 mg， every 3 weeks） based on the control group； for all patients， the treatment was stopped until disease progression or intolerable side effects occurred. The clinical efficacy， progression-free survival （PFS）， total survival （OS） and 1-year survival rate of the two groups were compared， and the incidence of adverse reactions in two groups， and immune-related adverse reactions in the study group during treatment were recorded. RESULTS The objective remission rate of the study group was significantly higher than the control group （36.7% vs. 13.3%， P＜0.05）， and the median OS and median PFS were significantly longer than the control group （OS： 12.6 months vs. 7.9 months； PFS： 8.2 months vs. 5.3 months， P＜0.05）. There was no significant difference in the 1-year survival rate and the incidence of elevated aspartate aminotransferase and alanine aminotransferase， rash or pruritus， anorexia， diarrhea， fatigue and hypertension between the two groups （P＞0.05）. The adverse events immune-related in the study group mainly included 21 cases of reactive capillary hyperplasia （70.0%）， 6 cases of hypothyroidism （20.0%）， and 1 case of immune-associated pneumonia （3.3%）， which were improved or tolerable after symptomatic treatment. CONCLUSIONS Camrelizumab combined with sorafenib in the treatment of advanced liver cancer can effectively control and delay the disease progression， prolong the survival period of patients， and the adverse reactions can be tolerated. |
| 期刊： | 2024年第35卷第12期 |
| 作者： | 邹瑜斌；杨灵；肖池金 |
| AUTHORS： | ZOU Yubin，YANG Ling，XIAO Chijin |
| 关键字： | 索拉非尼；卡瑞利珠单抗；肝癌；晚期；生存期；疗效；安全性 |
| KEYWORDS： | sorafenib； camrelizumab； liver cancer； advanced； survival period； therapeutic effect； safety |
| 阅读数： | 22 次 |
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