结合外泌体的微针经皮给药系统研究进展
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篇名: 结合外泌体的微针经皮给药系统研究进展
TITLE: Research progress of exosome microneedle drug delivery system
摘要: 微针可以穿透皮肤屏障给药而不触及痛觉神经,有效提高经皮给药效率,改善患者依从性。外泌体具有多种生理功能且具备良好的生物相容性,是天然纳米级药物载体。本文综述了外泌体结合微针治疗疾病的途径与优势,阐述了结合外泌体的微针经皮给药系统(以下简称为外泌体微针给药系统)在各类疾病中的研究现状。外泌体微针给药系统可分为以外泌体作为治疗剂和以外泌体作为药物载体两大类:前者因外泌体独特的生理来源可以有效避免常规药物毒性及免疫原性等问题,结合微针后可直接在特定部位给药,从而大大改善口服给药的代谢消耗和注射给药的患者依从性问题;后者因外泌体的天然囊泡结构及内源性特征可保护外来药物在体内的代谢并增强靶向性,结合微针后可有效解决疗效好但稳定性差的药物的经皮给药问题。外泌体微针给药系统目前仍处于实验室阶段,但其在修复脊髓损伤、促进糖尿病溃疡伤口愈合、生发、干预心肌梗死、缓解慢性疼痛等方面展现出良好的发展前景。
ABSTRACT: Microneedles can penetrate the skin barrier to deliver drugs without touching the nociceptive nerves, to effectively increase the efficiency of transdermal drug delivery and improve patient compliance. Exosomes have multiple physiological functions and good biocompatibility, and are natural nanoscale drug carriers. This paper reviews the pathways and advantages of exosomes combined with microneedles for the treatment of diseases, and describes the current research status of exosome microneedle drug delivery system in various diseases. Exosome microneedles can be divided into two categories: (1) exosomes as therapeutic agents, their unique physiological origin can effectively avoid the toxicity and immunogenicity of conventional drugs and other problems; combined with microneedles directly in the specific medication site can greatly improve the metabolic consumption of oral drug delivery and patient compliance of injection drug delivery. (2) Exosomes as drug carriers, their natural vesicle structure and endogenous characteristics can protect the metabolism of foreign drugs in the body and enhance the targeting; combined with microneedles can effectively solve the problem of transdermal delivery of drugs with high efficacy but poor stability. Exosome microneedle drug delivery system is still in the laboratory stage, but it has shown great development prospects in repairing spinal cord injury, promoting diabetic ulcer wound healing, germinating, intervening myocardial infraction, relieving chronic pain and other diseases.
期刊: 2024年第35卷第13期
作者: 文武龙;张炜烨;孙鑫;梁霄;杨婧;王锐
AUTHORS: WEN Wulong,ZHANG Weiye,SUN Xin,LIANG Xiao,YANG Jing,WANG Rui
关键字: 微针;外泌体;经皮给药;载药系统
KEYWORDS: microneedle; exosome; percutaneous administration; drug loading system
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