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纳米孔测序在病原微生物检测中的应用专家共识
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| 篇名： | 纳米孔测序在病原微生物检测中的应用专家共识 |
| TITLE： | Expert consensuses on the application of nanopore sequencing technology in the detection of pathogenic micro-organisms |
| 摘要： | 目的 提高危重症感染性疾病的诊断及救治水平，规范纳米孔测序的临床应用，促进该技术的良性发展。方法由中国药理学会治疗药物监测研究专业基层委员会和广东省药学会临床治疗精准用药专家委员会发起并组织多学科专家，采用名义群体法讨论确定共识编写大纲，形成共识初稿；采用德尔菲法进行专家咨询，对专家意见进行分析和修订，形成共识。结果与结论最终制定的《纳米孔测序在病原微生物检测中的应用专家共识》涵盖了靶向测序、宏基因组测序和全基因组测序等方向，对纳米孔测序的样本采集与保存、检测过程、生物信息学分析、报告解读等全流程进行了规范，并对其中的关键问题给出了推荐意见。 |
| ABSTRACT： | OBJECTIVE To improve the diagnosis and treatment level of critically ill infectious diseases， standardize the clinical application of nanopore sequencing and promote the sound development of the technology. METHODS Division of Therapeutic Drug Monitoring of Chinese Pharmacological Society and Expert Committee of Precision Medicine for Clinical Treatment of Guangdong Pharmaceutical Association initiated and organized multidisciplinary experts to discuss and determine the consensus writing outline by using the nominal group method， forming a preliminary consensus draft； expert consultation was performed by using Delphi method， and then experts’ opinions were analyzed and revised to form consensus. RESULTS & CONCLUSIONS Consensuses of Experts on the Application of Nanopore Sequencing Technology in the Detection of Pathogenic Microorganisms covers targeted sequencing， metagenomic sequencing and whole genome sequencing， and is standardized in terms of sample collection and storage， detection process， bioinformatics analysis and report interpretation； the recommendations are provided for the key issues. |
| 期刊： | 2024年第35卷第14期 |
| 作者： | 张述耀；侯铁英；黎小妍；钟诗龙；伍俊妍；黄 彬；中国药理学会治疗药物监测研究专业基层委员会；广东省药学会临床治疗精准用药专家委员会；《纳米孔测序在病原微生物检测中的应用专家共识》编写组 |
| AUTHORS： | ZHANG Shuyao， HOU Tieying，LI Xiaoyan，ZHONG Shilong，WU Junyan，HUANG Bin，Division of Therapeutic Drug Monitoring of Chinese Pharmacological Society，Expert Committee of Precision Medicine for Clinical Treatment of Guangdong Pharmaceutical Association，the W |
| 关键字： | 第三代测序；纳米孔测序；病原微生物；危重症感染；临床检验；微生物学诊断 |
| KEYWORDS： | third-generation sequencing； nanopore sequencing； pathogenic microorganisms； critical infection； clinical |
| 阅读数： | 11 次 |
| 本月下载数： | 4 次 |
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