中医药对慢性疼痛-抑郁共病的作用机制研究进展
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篇名: 中医药对慢性疼痛-抑郁共病的作用机制研究进展
TITLE: Advances in effect mechanism research of traditional Chinese medicine on comorbid depressive symptoms in chronic pain
摘要: 慢性疼痛是指持续或反复发作时间超过3个月的疼痛,与抑郁、焦虑等情绪具有高共病率。慢性疼痛-抑郁共病的发病机制错综复杂,给临床诊疗带来极大困扰。本文综述了近年中药单体和复方以及针刺疗法对慢性疼痛-抑郁共病作用机制的研究进展,发现中药单体(黄酮类、酚类、萜类、香豆素类、生物碱类化合物)、中药复方(乌头汤、柴胡桂枝汤等)及针刺疗法(针刺“百会”“印堂“”合谷“”太冲”等穴位)可以通过调节中枢神经系统中神经递质、脑源性神经营养因子、炎症因子的水平以及神经胶质细胞的活性,有效改善慢性疼痛-抑郁共病。
ABSTRACT: Chronic pain refers to pain that persists or recurs for more than 3 months and has a high comorbidity rate with emotions such as depression and anxiety. The complex pathogenesis of comorbid depressive symptoms in chronic pain poses great challenges to clinical diagnosis and treatment. This article reviews the research progress on the effect mechanism on the comorbid depressive symptoms in chronic pain by traditional Chinese medicine monomers, compound formulas, and acupuncture therapy in recent years. It is found that traditional Chinese medicine monomers (flavonoids, phenols, terpenes, coumarins, alkaloids), traditional Chinese medicine formulas (Aconitum carmichaeli decoction, Chaihu guizhi decoction, etc.), and acupuncture therapy (acupuncture at acupoints such as Baihui, Yintang, Hegu, and Taichong) can effectively improve comorbid depressive symptoms in chronic pain by regulating the levels of neurotransmitters, brain-derived neurotrophic factors and inflammatory factors, and the activity of glial cells in the central nervous system.
期刊: 2024年第35卷第19期
作者: 刘光华;史栋梁;傅文;王子华;崔家康
AUTHORS: LIU Guanghua,SHI Dongliang,FU Wen,WANG Zihua,CUI Jiakang
关键字: 慢性疼痛-抑郁共病;中药单体;中药复方;神经递质;炎症;作用机制
KEYWORDS: comorbid depressive symptoms in chronic pain; traditional Chinese medicine monomer; traditional Chinese
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