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直肠给药制剂治疗溃疡性结肠炎的研究进展
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| 篇名： | 直肠给药制剂治疗溃疡性结肠炎的研究进展 |
| TITLE： | Research progress on drug preparations of rectal administration for ulcerative colitis |
| 摘要： | 溃疡性结肠炎（UC）病因复杂，是国际消化系统领域的疑难病症之一。近年来，直肠给药制剂在UC治疗的应用中发展迅速。本文综述了治疗UC的直肠给药制剂的剂型、作用机制以及临床应用情况，发现栓剂是直肠给药中最常用的剂型，新型栓剂具备生物利用度高、稳定性好的优势；灌肠剂能尽可能地使药物在肠道内保留，以达到稀释肠内毒素、清理肠道、减轻炎症等作用；凝胶剂可实现药物缓释效果，并能有效改善肠黏膜损伤。该类制剂的作用机制主要为抑制炎症细胞浸润、调节肠道微生物稳态、增加紧密连接蛋白表达等，以此发挥抗炎、调节肠道菌群、修复肠黏膜等功效。直肠给药剂型的多样性（如美沙拉嗪栓剂、连芍灌肠剂、负载治疗UC药物的温敏凝胶剂等）为临床治疗UC提供了广泛选择。 |
| ABSTRACT： | Ulcerative colitis （UC）， which is characterized by a complex and multifactorial etiology， remains one of the challenging disorders in the international field of digestive system diseases. In recent years， rectal administration preparations have made rapid progress in UC therapeutic applications. This study systematically reviews the dosage forms， mechanisms of action， and clinical applications of rectally-administered preparations for the treatment of UC. It is found that suppositories are the most commonly used dosage forms for rectal administration. The newer suppositories have the advantages of high bioavailability and good stability. Enemas can retain the drug in the intestine as much as possible to achieve the effects of diluting intestinal toxins， cleansing the bowel， and reducing inflammation. Gels can achieve a drug-sustained-release effect and effectively improve intestinal mucosal damage. The mechanism of action of this type of preparation is mainly to inhibit inflammatory cell infiltration， regulate intestinal microbial homeostasis， and increase the expression of tight-junction proteins， so as to play anti-inflammatory， regulate the intestinal bacterial flora， repair the intestinal mucosa， and other efficacies. The diversity of rectal administration forms provides a wide range of choices for the clinical treatment of UC， such as Mesalazine suppositories， Lianshao enemas， and temperature- sensitive gels loaded with drugs for UC. |
| 期刊： | 2025年第36卷第07期 |
| 作者： | 万军；周丽莎；罗甜甜；张馨月；陈诗瑶；周霞 |
| AUTHORS： | WAN Jun，ZHOU Lisha，LUO Tiantian，ZHANG Xinyue，CHEN Shiyao，ZHOU Xia |
| 关键字： | 直肠给药；溃疡性结肠炎；药物制剂；作用机制；栓剂；灌肠剂；凝胶剂 |
| KEYWORDS： | rectal administration； ulcerative colitis； drug preparations； mechanism of action； suppository； enema； gel |
| 阅读数： | 17 次 |
| 本月下载数： | 2 次 |
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