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神香草对肺部疾病的干预作用机制与临床应用研究进展
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| 篇名： | 神香草对肺部疾病的干预作用机制与临床应用研究进展 |
| TITLE： | Research progress on the intervention mechanism and clinical application of Hyssopus cuspidatus in pulmonary disease |
| 摘要： | 神香草是新疆道地药材，富含黄酮类、酚酸类和萜类活性成分，具有抗炎、抗氧化和调节免疫的作用。现代药理学研究表明，神香草可通过抑制气道炎症反应、抑制气道重塑、调节下丘脑-垂体-肾上腺轴功能、松弛支气管平滑肌，发挥干预哮喘的作用；可通过降低炎症因子水平、调节免疫平衡等，发挥干预慢性阻塞性肺疾病的作用；可通过抑制氧化应激，发挥干预急性肺损伤的作用；可通过抑制肺癌细胞增殖、促进肺癌细胞凋亡，发挥干预肺癌的作用。临床应用方面，神香草复方制剂（如寒喘祖帕颗粒、罗欧咳祖帕）对哮喘、咳嗽、小儿支气管肺炎等肺部疾病具有良好的治疗效果。目前对神香草精确作用靶点及复方配伍规律的研究仍不充分，未来需结合代谢组学等现代技术深入探索，以推动这一传统药物的现代化开发和临床应用。 |
| ABSTRACT： | Hyssopus cuspidatus is an authentic medicinal herb used in Xinjiang， rich in the chemical constituents including flavonoids， phenolic acids and terpenoids. It possesses anti-inflammatory， antioxidant， and immunomodulatory effects. Modern pharmacological studies have demonstrated that H. cuspidatus exerts therapeutic effects on asthma by inhibiting airway inflammatory responses， suppressing airway remodeling， modulating the function of the hypothalamic-pituitary-adrenal axis， and relaxing bronchial smooth muscle. It also demonstrates intervention effects on chronic obstructive pulmonary disease by reducing levels of inflammatory cytokines and regulating immune balance. Additionally， H. cuspidatus can mitigate acute lung injury by inhibiting oxidative stress and intervene in lung cancer by suppressing proliferation and promoting apoptosis of lung cancer cells. In terms of clinical application， compound preparations containing H. cuspidatus， such as Hanchuan zupa granules and Luo’ou kezupa， have demonstrated favorable therapeutic effects on pulmonary diseases including asthma， cough， and pediatric bronchopneumonia. Currently， the research on precise action targets and compound matching rules of H. cuspidatus remains inadequate. Future studies should integrate modern technologies such as metabolomics to conduct in-depth exploration， thereby promoting the modernized development and clinical application of this traditional medicinal herb. |
| 期刊： | 2025年第36卷第23期 |
| 作者： | 赵蓉蓉；谭为；李海芳；丁曼；胡延孟；贺金华 |
| AUTHORS： | ZHAO Rongrong，TAN Wei，LI Haifang，DING Man，HU Yanmeng，HE Jinhua |
| 关键字： | 神香草；肺部疾病；复方制剂；哮喘；慢性阻塞性肺疾病；急性肺损伤；作用机制；临床应用 |
| KEYWORDS： | Hyssopus cuspidatus； pulmonary diseases； |
| 阅读数： | 11 次 |
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