Mohnarin脑脊液分离菌耐药性的动态分析
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篇名: | Mohnarin脑脊液分离菌耐药性的动态分析 |
TITLE: | |
摘要: | 目的:为临床控制感染与经验治疗提供参考。方法:收集2006-2011年Mohnarin 脑脊液分离菌报告文献资料,用SPSS.19.0软件进行统计。结果:我国2006-2011年临床脑脊液分离菌中革兰阳性(G+)菌呈上升趋势,革兰阴性(G-菌)呈下降趋势,且差异有统计学意义(χ2=12.952,P=0.01)。葡萄球菌耐药率总体出现明显逐年下降的趋势,差异有统计学意义(P<0.001) ,尤其是红霉素,对左氧氟沙星和环丙沙星的耐药率略有下降,但差异无统计学意义(P>0.05);未发现金黄色葡萄球菌耐万古霉素、利奈唑胺菌株。肠球菌对万古霉素的耐药率明显上升,差异有统计学意义(P<0.001),对左氧氟沙星耐药率差异无统计学意义(P>0.05),未发现耐利奈唑胺菌株。G-菌对常用抗菌药物的耐药性均呈逐年上升趋势,以不动杆菌属多重耐药的情况较为严重,其对常用抗菌药物的耐药性明显逐年升高,差异有统计学意义(P<0.001)。结论:我国脑脊液的临床分离菌中表皮葡萄球菌和不动杆菌属逐年增多,脑脊液的临床分离菌G+菌耐药性大部分呈下降趋势,G-菌均呈现明显增加趋势。 |
ABSTRACT: | OBJECTIVE: To provide reference for clinical infection control and experiential therapy. METHODS: From 2006 to 2011, Mohnarin cerebrospinal fluid (CSF) isolates reports and literatures were collected and analyzed statistically by using SPSS.19.0 software. RESULTS: During 2006-2011, Gram-positive bacteria in CSF isolates were on the rise, and Gram-negative bacteria were decreased, with statistical significance (χ2=12.952,P=0.01). Resistance rate of Staphylococcus showed a significant decrease trend, with statistical significance (P<0.001), especially to Erythromycin. Resistance rate of Staphylococcus to levofloxacin and ciprofloxacin had declined slightly, but there was no statistical significance (P>0.05). That Staphylococcus aureus resistant to vancomycin and linezolid had not been found. Resistance rate of Enterococcus to vancomycin increased significantly, with statistical significance (P<0.001); to levofloxacin, there was no statistical significance (P>0.05); linezolid-resistant strains was not found. Resistance rate of Gram-negative bacterial to antibiotics increased gradually year by year, especially multiple drug resistance of Acinetobacter; that of Acinetobacter to commonly used antibiotics increased significantly, with statistical significance (P<0.001). CONCLUSIONS: Among CSF clinical isolates, Staphylococcus epidermis and Acinetobacter are increasing year by year; drug resistance of Gram-positive bacteria show a downward trend, while Gram-negative bacteria tend to increase significantly. |
期刊: | 2016年第27卷第2期 |
作者: | 陈丽霞,明德松,龚国梅,邱伟智,黄东红,王翠娥,林美 |
AUTHORS: | CHEN Lixia,MING Desong,GONG Guomei,QIU Weizhi,HUANG Donghong,WANG Cuie,LIN Mei |
关键字: | 全国细菌耐药性监测网脑脊液;微生物;抗菌药物;耐药性;动态分析 |
KEYWORDS: | Mohnarin cerebrospinal fluid;Microorganism;Antibiotics;Drug resistance; Dynamic analysis |
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