注射用奥扎格雷钠与含果糖注射液的配伍稳定性考察
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篇名: 注射用奥扎格雷钠与含果糖注射液的配伍稳定性考察
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摘要: 目的:考察注射用奥扎格雷钠与3种含果糖注射液的配伍稳定性。方法:将注射用奥扎格雷钠分别与5%果糖注射液、5%果糖氯化钠注射液及5%转化糖注射液配伍后,置25 ℃恒温水浴箱中,于0、1、2、4、6 h时观察配伍液外观变化,测定配伍液pH值,并采用高效液相色谱(HPLC)法测定配伍液中奥扎格雷钠的含量。结果:注射用奥扎格雷钠与上述3种注射液配伍6 h内外观无明显变化,pH值变化范围在0.002~0.156之间,含量由100%下降至95.7%。结论:注射用奥扎格雷钠与5%果糖注射液、5%果糖氯化钠注射液和5%转化糖注射液分别配伍后随时间的变化,奥扎格雷钠含量呈减少的趋势,建议在实际应用中应在配伍后6 h内滴注完毕。
ABSTRACT: OBJECTIVE: To investigate the compatibility stability of ozagrel sodium for injection with 3 kinds of injection containing fructose. METHODS: Ozagrel sodium for injection was mixed with 5% fructose injection, 5% fructose and sodium chloride injection and 5% calorose injection respectively, and then placed in constant temperature water bath at 25 ℃; 0,1,2,4,6 h later, the appearance and pH of mixture were observed and determined, and HPLC method was adopted to determine the content of ozagrel sodium in mixture. RESULTS: There was no significant changes in appearance, and pH ranged from 0.002 to 0.156, the content decreased from 100% to 95.7%within 6 hours after ozagrel sodium for injection mixed with 3 kinds of injection. CONCLUSIONS: After ozagrel sodium for injection mixed with 5% fructose injection, 5% fructose and sodium chloride injection and 5% calorose injection, the content of ozagrel sodium decrease gradually as times. In the practice, the mixture should be used up within 6 h.
期刊: 2016年第27卷第2期
作者: 王成湖,易林高
AUTHORS: WANG Chenghu,YI Lingao
关键字: 奥扎格雷钠;配伍;稳定性;高效液相色谱法;含量
KEYWORDS: Ozagrel sodium; Compatibility; Stability; HPLC; Content
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