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丹参酮ⅡA磺酸钠治疗冠心病心绞痛的临床观察
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| 篇名： | 丹参酮ⅡA磺酸钠治疗冠心病心绞痛的临床观察 |
| TITLE： | |
| 摘要： | 目的：观察丹参酮ⅡA磺酸钠治疗冠状动脉粥样硬化性心脏病（简称“冠心病”）心绞痛的临床疗效及安全性。方法：46例冠心病心绞痛患者入组疗效评价组，并按随机数字表法分为试验组（23例）和对照组（23例）；另将45例冠心病心绞痛患者入组安全性评价组。所有患者均采用硝酸异山梨酯、阿司匹林、β受体阻滞药等常规药物治疗；试验组患者在常规治疗的同时应用丹参酮ⅡA磺酸钠注射液40 mg静脉滴注，qd，连续4 d。观察两组患者用药前后心绞痛发作频率、心绞痛持续时间、心电图以及可能存在的不良反应。安全性评价组患者治疗方案中包含丹参酮ⅡA磺酸钠注射液，剂量频次与试验组相同，不限定疗程，该组患者仅观察不良反应发生情况。结果：试验组患者心绞痛与心电图临床疗效的总有效率分别为86.96％、69.56％，显著高于对照组的65.22％、43.48％，差异有统计学意义（P＜0.05）。与对照组比较，试验组患者治疗后的心绞痛发作次数明显减少，发作持续时间明显缩短，差异有统计学意义（P＜0.01）。68例静脉滴注丹参酮ⅡA磺酸钠注射液的患者均未见不良反应发生。结论：在常规治疗冠心病心绞痛的基础上联合丹参酮ⅡA磺酸钠注射液治疗，能有效改善冠心病心绞痛的临床症状，且安全性较高。 |
| ABSTRACT： | OBJECTIVE： To observe the clinical efficacy and safety of tanshinone ⅡA sulfonate in the treatment of coronary atherosclerotic heart disease （CHD） angina. METHODS： 46 patients with CHD angina were included in efficacy evaluation group， and randomly assigned into trial group （23 cases） and control group （23 cases）； other 45 patients with CHD angina were enrolled into safety evaluation group. All of them were treated with conventional therapy of isosorbide dinitrate， aspirin and β receptor blocker， etc.； trial group was additionally given Tanshinone ⅡA sulfonate injection intravenously， qd， for consecutive 4 d on the basis of routine therapy. The frequency and period of angina attacks， ECG before and after treatment and potential ADR were observed in 2 groups. Safety evaluation group were treated with Tanshinone ⅡA sulfonate injection with same dosage and frequency as trial group， but treatment course was not limited； only the occurrence of ADR was observed in the group. RESULTS： The total effective rates of clinical efficacy and ECG in trial group were 86.96％ and 69.56％， which were significantly higher than the control group （65.22％， 43.48％）， with statistical significance （P＜0.05）. Compared with control group， the frequency and period of angina attacks reduced significantly in trial group after treatment， with statistical significance （P＜0.01）. No ADR was observed in 68 patients treated with intravenous dripping of Tanshinone ⅡA sulfonate injection. CONCLUSIONS： Based on routine therapy， Tanshinone ⅡA sulfonate injection can effectively improve the clinical symptom of CHD angina， with good safety. |
| 期刊： | 2016年第27卷第2期 |
| 作者： | 黄菁菁，张伟霞，杨婉花 |
| AUTHORS： | HUANG Jingjing，ZHANG Weixia，YANG Wanhua |
| 关键字： | 冠状动脉粥样硬化性心脏病；心绞痛；丹参酮ⅡA磺酸钠注射液；疗效 |
| KEYWORDS： | Coronary atherosclerotic heart disease； Angina； Tanshinone ⅡA sulfonate injection； Efficacy |
| 阅读数： | 297 次 |
| 本月下载数： | 2 次 |
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