艾塞那肽对不同体质量指数2型糖尿病患者代谢指标的影响
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篇名: 艾塞那肽对不同体质量指数2型糖尿病患者代谢指标的影响
TITLE:
摘要: 目的:探讨艾塞那肽对不同体质量指数(BMI)2型糖尿病患者代谢指标的影响。方法:106例2型糖尿病患者按照不同BMI分为正常组(35例)、超重组(35例)和肥胖组(36例)。在原有降糖治疗基础上,给予3组患者艾塞那肽治疗。比较3组患者治疗前后的血压、体质量、BMI、各项血糖指标及甘油三酯水平,并观察其不良反应发生情况。结果:超重组与肥胖组患者治疗后的血压、体质量、BMI均显著优于治疗前,差异具有统计学意义(P<0.05)。3组患者治疗后的空腹血糖、餐后2 h血糖、糖化血红蛋白、甘油三酯水平均显著低于治疗前,差异具有统计学意义(P<0.05)。超重组与肥胖组患者的体质量和BMI变化幅度均显著大于正常组,差异具有统计学意义(P<0.05)。3组患者均未出现严重并发症。结论:艾塞那肽适合于超重、肥胖2型糖尿病患者的治疗。
ABSTRACT: OBJECTIVE: To explore the effects of Metabolic index of exenatide on body mass index (BMI) of type 2 diabetes patients. METHODS: According to different BMI, 106 patients with type 2 diabetes were divided into normal group (35 cases), overweight group (35 cases) and obesity group (36 cases). Based on previous hypoglycemic therapy, 3 groups received exenatide. Blood pressure, body weight, BMI, blood glucose index, TG and ADR were compared among 3 groups. RESULTS: After treatment, blood pressure, body weight and BMI of overweight group and obesity group were significantly better than before, with statistical significance (P<0.05); fasting blood glucose, postprandial 2 h blood glucose, glycosylated hemoglobin, triglycerides of 3 group were significantly lower than before, with statistical significance (P<0.05). Changes of body weight and BMI in overweight group and obesity group were significantly higher than in normal group, with statistical significance (P<0.05). No serious complications was found in 3 groups. CONCLUSIONS: The therapy of exenatide is suitable for overweight and obese type 2 diabetic patients.
期刊: 2016年第27卷第2期
作者: 罗志芳,董志春,司令
AUTHORS: LUO Zhifang,DONG Zhichun,SI Ling
关键字: 体质量指数;2型糖尿病;艾塞那肽;超重;肥胖
KEYWORDS: Body mass index; Type 2 diabetes; Exenatide; Overweight; Obesity
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