血药浓度监测在肝衰竭患者应用伏立康唑治疗肺部感染中的作用
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篇名: 血药浓度监测在肝衰竭患者应用伏立康唑治疗肺部感染中的作用
TITLE:
摘要: 目的:探讨临床药师进行血药浓度监测在肝衰竭患者应用伏立康唑治疗侵袭性肺部真菌感染中的作用。方法:临床药师在参与使用伏立康唑治疗侵袭性曲霉菌病合并肝衰竭患者的过程中,定期监测患者血药浓度,排查不良反应原因,协助医师为患者调整伏立康唑用药方案,评价药物治疗效果。结果:医师采纳临床药师建议,患者不良反应症状消失,避免了伏立康唑的蓄积中毒,感染好转。结论:临床药师参与治疗过程、进行血药浓度监测对药物治疗有指导作用,可确保患者用药安全、有效。
ABSTRACT: OBJECTIVE: To explore the process of clinical pharmacists participating in the voriconazole anti-fungal therapy for patients with liver failure. METHODS: Clinical pharmacists participated in the voriconazole therapy for patients with invasive Aspergillus disease complicated with liver failure, monitored blood concentration regularly, check the reasons for ADR, assisted physicians to adjust voriconazole therapy plan and evaluate therapeutic efficacy. RESULTS: Physicians adopted the suggestion of clinical pharmacists, and patient’s ADR disappeared to avoid cumulative intoxication of voriconazole and promote infection recovery. CONCLUSIONS: Clinical pharmacists participate in treatment and carry out blood concentration monitoring to guide drug therapy and guarantee the safety and effectiveness of drug use.
期刊: 2016年第27卷第2期
作者: 彭文绣,任秋霞,李璇,叶郁芊,朱红,刘峰群
AUTHORS: PENG Wenxiu,REN Qiuxia,LI Xuan,YE Yuqian,ZHU Hong,LIU Fengqun
关键字: 肝衰竭;伏立康唑;血药浓度监测;药学监护;不良反应
KEYWORDS: Liver failure; Voriconazole; Blood concentration monitoring; Pharmaceutical care; ADR
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