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依达拉奉联合胞磷胆碱钠治疗急性脑梗死的临床观察
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| 篇名： | 依达拉奉联合胞磷胆碱钠治疗急性脑梗死的临床观察 |
| TITLE： | |
| 摘要： | 目的：探讨依达拉奉联合胞磷胆碱钠治疗急性脑梗死的疗效及其对氧化应激和炎性因子指标的影响。方法：108例急性脑梗死患者依据随机数字表法分为依达拉奉组（单独组）和依达拉奉+胞磷胆碱钠组（联合组），各54例。在常规治疗基础上，单独组患者给予依达拉奉注射液30 mg加入100 ml 0.9％氯化钠注射液中静脉滴注，每次在30 min之内滴完，bid；联合组患者在单独组治疗基础上加用胞磷胆碱钠注射液0.5 g加入250 ml 0.9％氯化钠注射液中静脉滴注，qd。两组患者疗程均为2周。比较两组患者治疗前后美国国立卫生研究院卒中量表（NIHSS），并据此评定的疗效、长谷川智能量表（HDS）评分、日常生活力能评定量表（Barthel指数）、氧化应激指标、炎性因子指标水平。结果：治疗后，联合组患者的有效率为81.48％，显著高于单独组（53.70％），差异有统计学意义（χ2＝9.511， P＝0.002）。两组患者的HDS评分和Barthel指数均较治疗前显著增加，且联合组更优，差异有统计学意义（P＜0.05）。与治疗前比较，两组患者的丙二醛、内皮素-1含量显著降低，超氧化物歧化酶、一氧化氮含量显著升高，炎性因子白细胞介素（IL）-6、IL-8、IL-12、IL-16和肿瘤坏死因子α水平显著降低，差异均有统计学意义（P＜0.05）；且联合组患者各指标的改善程度均明显优于单独组，差异有统计学意义（P＜0.05）。结论：依达拉奉联合胞磷胆碱钠治疗急性脑梗死的疗效良好，且能降低氧化应激和炎症水平，更有利于患者神经功能和日常生活能力的恢复。 |
| ABSTRACT： | OBJECTIVE： To investigate the therapeutic efficacy of edaravone combined with citicoline sodium on acute cerebral infarction and its effects on the levels of oxidative stress and inflammatory factors. METHODS： 108 patients with acute cerebral infarction were randomly divided into edaravone group （single group） and edaravone+citicoline sodium group （drug combination group）， with 54 cases in each group. Based on routine treatment， single group was given Edaravone injection 30 mg added into 100 ml 0.9％ Sodium chloride injection intravenously， bid， used up within 30 min each time； drug combination group was additionally given Citicoline sodium injection 0.5 g added into 250 ml 0.9％ Sodium chloride injection intravenously， qd， on the basis of single group. Treatment course of 2 groups lasted for 2 weeks. NIHSS， HDS， Barthel index， oxidant stress indicator and inflammatory factors were compared between 2 groups before and after treatment. RESULTS： After treatment， the effective rate of NIHSS in drug combination group was 81.48％， which was significantly higher than single group （53.70％）， with statistical significance （χ2＝9.511， P＝0.002）. HDS score and Barthel index of 2 groups were significantly increased after treatment， especially in drug combination group， with statistical significance （P＜0.05）. Compared with before treatment， contents of MDA and ET-1 in 2 groups were decreased significantly， while SOD activity and NO content were increased significantly； the inflammatory cytokines IL-6， IL-8， IL-12 and IL-16， TNF-α were all decreased gradually， with statistical significance （P＜0.05）； the improvement of each indicator in drug combination group was more significant than single group， with statistical significance （P＜0.05）. CONCLUSIONS： Edaravone combined with citicoline sodium show good therapeutic efficacy in the treatment of acute cerebral infarction， can decrease the levels of oxidative stress and inflammation and promote the recovery of the neurological function and the daily living ability. |
| 期刊： | 2016年第27卷第8期 |
| 作者： | 谭庆晶，季兴，江志滨，卢峰，张德敏，李琳钰，李波 |
| AUTHORS： | TAN Qingjing，JI Xing，JIANG Zhibin，LU Feng，ZHANG Demin，LI Linyu，LI Bo |
| 关键字： | 依达拉奉；胞磷胆碱钠；联合用药；急性脑梗死；疗效；氧化应激；炎性因子 |
| KEYWORDS： | Edaravone； Citicoline sodium； Drug combination； Acute cerebral infarction； Therapeutic efficacy； Oxidative stress； Inflammatory factors |
| 阅读数： | 1389 次 |
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