我院124株铜绿假单胞菌分布及耐药性分析
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篇名: | 我院124株铜绿假单胞菌分布及耐药性分析 |
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摘要: | 目的:探讨医院感染铜绿假单胞菌的分布及耐药性情况,为临床合理用药提供科学理论依据。方法:收集2013年4月-2014年4月我院门诊及住院患者送检的痰液、胸水、尿液、创面及伤口分泌物、血液等培养分离的铜绿假单胞菌124株,按照《全国临床检验操作规程》(2版)方法对铜绿假单胞菌进行培养与鉴定,采用纸片扩散(K-B)法进行药敏试验。结果:124株铜绿假单胞菌主要分布在重症监护病房(ICU)(23株,18.55%)、呼吸内科(17株,13.71%)和脑外科(14株,11.29%);检出感染部位主要为痰液、创面及伤口分泌物。铜绿假单胞菌对头孢噻肟、头孢吡肟、氨曲南的耐药率均>50%。结论:铜绿假单胞菌耐药性已非常严重,在药物治疗过程中,须定期监测抗菌药物的敏感性变化,针对不同病区、不同患者实行抗菌药物交替使用,尽量防止耐药菌株产生和蔓延,以提高或巩固药物治疗效果。 |
ABSTRACT: | OBJECTIVE: To investigate the distribution and drug resistance of Pseudomonas aeruginosa in nosocomial infections to provide the scientific evidence for the clinical use of the antibiotics. METHODS: 124 strains of P. aeruginosa were isolated from sputum, hydrothorax, urine, wound secretion, blood and so on submitted by outpatient and inpatient department of our hospital during Apr. 2013-Apr. 2014. Isolated P. aeruginosa were cultured and identified according to National Rules of Clinical Laboratory Procedures (2nd edition), and drug resistance was analyzed by K-B method. RESULTS: A total of 124 strains of P. aeruginosa mainly isolated from ICU (23 strains, 18.55%), respiratory medicine department (17 strains, 13.71%) and brain surgery department (14 strains, 11.29%). Sites of infection were sputum, wound secretion. Resistance rate of P. aeruginosa to cefotaxime, cefepime and aztreonam were over 50%. CONCLUSIONS: Drug resistance of P. aeruginosa is very serious. During drug therapy, it is necessary to monitor antibiotics sensitivity regularly, and use antibiotics alternatively for different patients in different wards, in order to prevent the generation and spread of drug-resistant strain as far as possible, and improve or consolidate therapeutic efficacy. |
期刊: | 2016年第27卷第11期 |
作者: | 王奇年 |
AUTHORS: | WANG Qinian |
关键字: | 医院感染;铜绿假单胞菌;分布;耐药性 |
KEYWORDS: | Nosocomial infections; Pseudomonas aeruginosa; Distribution; Drug resistance |
阅读数: | 362 次 |
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