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阿戈美拉汀与帕罗西汀对首发抑郁症患者认知功能的影响
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| 篇名： | 阿戈美拉汀与帕罗西汀对首发抑郁症患者认知功能的影响 |
| TITLE： | |
| 摘要： | 目的：比较阿戈美拉汀与帕罗西汀对首发抑郁症患者认知功能的影响及安全性。方法：将84例首发抑郁症患者按随机数字表法分为阿戈美拉汀组（43例）和帕罗西汀组（41例）。阿戈美拉汀组患者给予阿戈美拉汀片，初始剂量25 mg，2周后增至25～50 mg，qd；帕罗西汀组患者给予帕罗西汀片，初始剂量20 mg，2周后增至25～50 mg，qd。两组患者均连续治疗6周，治疗期间不合用其他抗抑郁药治疗。观察两组患者治疗前后数字划销测验（NCT）评分、修订韦氏成人记忆量表（WMS-RC）评分、蒙特利尔认知评估量表（MoCA）评分及不良反应发生情况。结果：治疗前，两组患者NCT、WMS-RC、MoCA各项评分比较，差异无统计学意义（P＞0.05）；治疗后，两组患者NCT、WMS-RC、MoCA各项评分均显著提高，NCT失误率显著降低，差异有统计学意义（P＜0.05）。治疗后，阿戈美拉汀组患者NCT失误率低于帕罗西汀组，NCT、WMS-RC、MoCA总评分及注意、记忆、延迟记忆评分均高于帕罗西汀组，差异有统计学意义（P＜0.05）。阿戈美拉汀组患者不良反应发生率显著低于帕罗西汀组，差异有统计学意义（P＜0.05）。结论：阿戈美拉汀在改善首发抑郁症患者认知功能及安全性方面均优于帕罗西汀。 |
| ABSTRACT： | OBJECTIVE： To compare the effect and safety of agomelatine and paroxetine on cognitive function in first-episode depression patients. METHODS： 84 first-episode depression patients were randomly divided into agomelatine group（43 cases） and paroxetine group（41 cases）. Agomelatine group was given Agomelatine tablet with initial dose of 25 mg， increasing to 50 mg 2 weeks later， qd； paroxetine group was given paroxetine with initial dose of 20 mg， increasing to 50 mg 2 weeks later， qd. Treatment course of 2 groups lasted for 6 weeks. They were not given any other anti-depression agent. NCT， WMS-RC and MoCA score and the occurrence of ADR were observed in 2 groups before and after treatment. RESULTS： There was no statistical significance in NCT， WMS-RC and MoCA between 2 groups before treatment （P＞0.05）； after treatment， those of 2 groups improved significantly， and the rate of NCT error reduced significantly， with statistical significance （P＜0.05）. After treatment， the rate of NCT error in agomelatine group was lower than in paroxetine group， while the NCT， WMS-RC， MoCA scores and attention， recall and delayed recall score were higher than paroxetine group， with statistical significance （P＜0.05）. The incidence of ADR in agomelatine group was significantly lower than in paroxetine group， with statistical significance （P＜0.05）. CONCLUSIONS： Agomelatine is better than paroxetine in improving the first-episode depression patients in cognitive function and safety. |
| 期刊： | 2016年第27卷第11期 |
| 作者： | 孙磊，陈清刚，王莹，杨建立 |
| AUTHORS： | SUN Lei，CHEN Qinggang，WANG Ying，YANG Jianli |
| 关键字： | 首发抑郁症；阿戈美拉汀；帕罗西汀；认知功能 |
| KEYWORDS： | First-episode depression； Agomelatine； Paroxetine； Cognitive function |
| 阅读数： | 876 次 |
| 本月下载数： | 5 次 |
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