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二甲双胍对肥胖型2型糖尿病患者相关指标的影响
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| 篇名： | 二甲双胍对肥胖型2型糖尿病患者相关指标的影响 |
| TITLE： | |
| 摘要： | 目的：探讨二甲双胍对肥胖型2型糖尿病患者相关指标的影响。 方法： 136例肥胖型2型糖尿病患者随机均分为对照组和观察组。所有患者均完善常规检查，进行糖尿病常规教育，控制饮食、加强运动锻炼。在此基础上，对照组患者给予格列齐特片（Ⅱ）80 mg，每日1次，并实时监测血糖水平，根据空腹血糖水平调整用药量，使空腹血糖达到3.9～6.1 mmol/L；观察组患者给予二甲双胍肠溶片0.5 g，每日2次。两组均治疗12周后比较。观察两组患者治疗前后糖化血红蛋白（HbA1c）、体质量指数（BMI）、抵抗素、胰岛素样生长因子1（IGF-1）及相关炎症因子[白细胞介素（IL）-1β、IL-6、肿瘤坏死因子（TNF）-α、超敏C反应蛋白（hs-CRP）]水平，并记录不良反应发生情况。结果：治疗后，两组患者抵抗素、IGF-1、IL-6、hs-CRP水平均显著低于同组治疗前，且观察组均低于对照组，差异均有统计学意义（P＜0.05）；观察组患者BMI、IL-1β、TNF-α水平均显著低于同组治疗前和对照组，差异均有统计学意义（P＜0.05）；两组患者HbA1c水平均显著低于同组治疗前，差异均有统计学意义（P＜0.05），但组间比较差异无统计学意义（P＞0.05）；两组患者不良反应发生率比较差异无统计学意义（P＞0.05）。结论：二甲双胍能够改善肥胖型2型糖尿病患者的胰岛素抵抗，抑制炎症反应。 |
| ABSTRACT： | OBJECTIVE： To observe the effect of metformin on related indicators of obese patients with type 2 diabetes. METHODS： 136 obese patients with type 2 diabetes were randomly divided into control group and observation group. All patients were given conventional examination， conventional education about diabetes， diet control and stressed physical exercise. Based on it， control group was given 80 mg Metformin tablet（Ⅱ），once a day， and monitored blood glucose levels， the dosage was adjusted based on fasting blood glucose levels to ensure blood glucose in 3.9-6.1 mmol/L； observation group was given 0.5 g Metformin enteric-coated tablet， twice a day. The 2 groups were compared after 12 weeks treatment. The glycated hemoglobin （HbA1c）， body mass index （BMI）， resistin， insulin-like growth factor-1（IGF-1）， inflammatory cytokines [interleukin-1β（IL-1β）， interleukin-6 （IL-6）， tumor necrosis factor-α （TNF-α）， high-sensitivity C-reactive protein （hs-CRP）] levels in 2 groups before and after tveatment were observed，and the incidence of adverse reactions in 2 groups was recorded. RESULTS： After treatment， resistin，IGF-1， IL-6 and hs-CRP levels in 2 groups were significantly lower than before， and observation group was lower than control group； the differences were statistically significant（P＜0.05）；BMI，IL-1β and TNF-α levels in obser vation group were significantly higher than before and control group， the differences were statistically significant（P＜0.05）； HbA1c level in 2 groups was significiantly lower than before，the difference was statistically significant（P＜0.05），but there was no significant difference between 2 groups（P＞0.05）； BMI level in observation group was lower than before and control group， and there was no significant difference in the incidence of adverse reactions between 2 groups（P＞0.05）. CONCLUSIONS： Metformin can effectively improve insulin resistance in obese patients with type 2 diabetes and inhibit the inflammatory reaction. |
| 期刊： | 2016年第27卷第12期 |
| 作者： | 孔永红，杨小东 |
| AUTHORS： | KONG Yonghong，YANG Xiaodong |
| 关键字： | 二甲双胍；肥胖型2型糖尿病；胰岛素样生长因子1；抵抗素；炎症因子 |
| KEYWORDS： | Metformin； Obese patients with type 2 diabetes； Insulin-like growth factor-1； Resistin； Inflammatory cytokines |
| 阅读数： | 225 次 |
| 本月下载数： | 3 次 |
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