茵栀黄口服液辅助治疗新生儿黄疸有效性和安全性的系统评价
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篇名: 茵栀黄口服液辅助治疗新生儿黄疸有效性和安全性的系统评价
TITLE:
摘要: 目的:系统评价茵栀黄口服液辅助治疗新生儿黄疸的有效性和安全性,以为临床提供循证参考。方法:计算机检索中国期刊全文数据库、中文科技期刊数据库、万方数据库、Medline和EMBase,收集在常规治疗(对照组)的基础上加用茵栀黄口服液(试验组)治疗新生儿黄疸有效性和安全性的随机对照试验(RCT),对符合纳入标准的临床研究进行资料提取,并采用改良后的Jadad量表进行质量评价,采用Rev Man 5.2统计软件进行Meta分析。结果:共纳入12项RCT,合计1 585例患儿。Meta分析结果显示,试验组患者总有效率[OR=0.19,95%CI(0.12,0.30),P<0.001]、血清总胆红素变化情况[MD=-40.78,95%CI(-42.68,-38.89),P<0.001]、胆红素下降至正常所需时间[MD=-2.56,95%CI(-2.72,-2.40),P<0.001]均显著优于对照组,差异均有统计学意义;不良反应方面有3项研究报道试验组部分患儿出现呕吐、轻度腹泻等症状,但不影响治疗。结论:茵栀黄口服液辅助治疗新生儿黄疸有效性较好,不良反应轻微。
ABSTRACT: OBJECTIVE:To systematically review the effectiveness and safety of Yinzhihuang oral liquid in the adjuvant treatment of neonatal jaundice, and provide evidence-based reference for clinical treatment. METHODS:Retrieved from CJFD, VIP Database, Wanfang Database, Medline and EMBase, randomized controlled trials (RCT) about the effectiveness of Yinzhihuang oral liquid (test group) based on the canventional treatment (control group) in the adjuvant treatment of neonatal jaundice were collected, and Meta-analysis was performed by using Rev Man 5.2 software after data extracting and quality evaluating by modified Jadad. RESULTS:Totally 12 RCTs were enrolled, involving 1 585 patients. Results of Meta-analysis showed total effective rate [OR=0.19,95%CI(0.12, 0.30),P<0.001], serum total bilirubin levels [MD=-40.78,95%CI(-42.68,-38.89),P<0.001] and time of bilirubin decreased to normal [MD=-2.56,95%CI(-2.72,-2.40),P<0.001] in test group were significantly better than control group, the differences were statistically significant between 2 groups; 3 reports of adverse reactions showed scme children had vomiting and mild diarrhea, they were improved after symptomatic treatment, and it did not affect the treatment. CONCLUSIONS: The effectiveness of Yinzhihuang oral liquid is good in the adjuvant treatment of neonatal jaundice, with mild adverse reactions.
期刊: 2016年第27卷第12期
作者: 唐文,谭建玲,贾亮亮,金桂兰
AUTHORS: TANG Wen,TAN Jianling,JIA Liangliang,JIN Guilan
关键字: 茵栀黄口服液;新生儿黄疸;有效性;安全性;系统评价
KEYWORDS: Yinzhihuang oral liquid; Neonatal jaundice; Effectiveness; Safety; Systematic review
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