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三维适形放疗中应用榄香烯对食管癌治疗效果的影响
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| 篇名： | 三维适形放疗中应用榄香烯对食管癌治疗效果的影响 |
| TITLE： | |
| 摘要： | 目的：观察三维适形放疗中应用榄香烯对食管癌的效果和安全性的影响。方法：92例食管癌患者按随机数字表法分为研究组50例与对照组42例。对照组患者行三维适形及三野照射治疗，研究组患者在对照组放疗基础上加用榄香烯注射液静脉注射，每次600 mg，qd，持续治疗1个月。观察两组患者治疗1个月后的临床疗效；随访1～3年，计算两组患者的生存率及肿瘤局部控制率；采用生存质量核心问卷（QLQ-C30）和食管癌补充模式表（QLQ-OES18）评价患者的生存质量和症状改善情况；观察两组患者治疗期间不良事件的发生情况。结果：研究组患者的有效率为88.0％，较对照组（66.7％）显著提高，差异有统计学意义（P＜0.05）。研究组患者随访1、2、3年的的肿瘤局部控制率和生存率较对照组高，但组间比较差异无统计学意义（P＞0.05）。研究组患者的躯体、情绪、角色、社会、认知功能评分显著高于对照组，疲劳、口干、吞咽梗阻、进食、食欲减退、吞咽困难症状评分显著低于对照组，组间比较差异均有统计学意义（P＜0.05）。两组患者不良事件发生率比较，差异无统计学意义（P＞0.05）。结论：榄香烯联合三维适形放疗用于食管癌的近远期疗效确切、安全性高，且有利于提高患者的生存率和生存质量。 |
| ABSTRACT： | OBJECTIVE： To observe the clinical effect of elemene for esophageal carcinoma in three-dimensional conformal radiotherapy. METHODS： 92 patients with esophageal carcinoma were randomly divided into research group （50 cases） and control group （42 cases）. Control group received three dimensional conformal and Sanye irradiation treatment； research group was additionally treated with Elemene injection intravenously， 600 mg/time， qd， for consecutive 1 month， on the basis of control group. Clinical efficacies of 2 groups were observed one month later. With a year to 3 years of follow-up， the local control rate and survival rate of 2 groups were calculated； QLQ-C30 and QLQ-OES18 were used to evaluate the survival quality and symptom improvement； the occurrence of adverse events were observed in 2 groups during treatment. RESULTS： The effective rate of research group was 88.0％ and increased significantly compared to control group （66.7％）， with statistical significance （P＜0.05）. With 1， 2 and 3 years of follow-up， local control rate and survival rate of research group were higher than those of control group， without statistical significance （P＞0.05）. The body， emotion， role， society and cognition score of research group were significantly higher than those of control group， while fatigue， dry mouth， deglutition obstruction， eating， loss of appetite and dysphagia score were significantly lower than control group， with statistical significance （P＜0.05）. There was no statistical significance in the incidence of adverse events between 2 groups （P＞0.05）. CONCLUSIONS： Elemene combined with three-dimensional conformal radiotherapy shows definite short-term and long-term efficacy and is highly safe for esophageal carcinoma， and it contributes to the improvement of survival rate and survival quality. |
| 期刊： | 2016年第27卷第14期 |
| 作者： | 朱向高，李金銮，陈彬璞，高莹，祝晓莲，陈亚林 |
| AUTHORS： | ZHU Xianggao，LI Jinluan，CHEN Binpu，GAO Ying，ZHU Xiaolian，CHEN Yalin |
| 关键字： | 榄香烯；三维适形放疗；食管癌；疗效；生存率；生存质量 |
| KEYWORDS： | Elemene； Three-dimensional conformal radiotherapy； Esophageal carcinoma； Clinical effect； Survival rate； Survival quality |
| 阅读数： | 237 次 |
| 本月下载数： | 1 次 |
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