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复方黄连降糖散治疗空腹血糖受损患者的临床观察
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| 篇名： | 复方黄连降糖散治疗空腹血糖受损患者的临床观察 |
| TITLE： | |
| 摘要： | 目的：观察复方黄连降糖散治疗空腹血糖（FBG）受损患者的临床疗效及安全性。方法：选取FBG受损患者122例，按随机数字表法分为对照组和试验组，各61例。两组患者均进行健康教育及饮食指导治疗；试验组患者加服复方黄连降糖散2.5 g，qd。两组患者均治疗4个月。观察两组患者临床疗效及治疗前后FBG、总胆固醇（TC）、三酰甘油（TG）、低密度脂蛋白胆固醇（LDL-C）、糖化血红蛋白（HbA1c）、超氧化物歧化酶（SOD）、丙二醛（MDA）及谷胱甘肽过氧化物酶（GSH-PX）水平及体质量指数（BMI），并记录不良反应情况。结果：试验组患者总有效率为77.0％，显著高于对照组的24.6％，差异有统计学意义（P＜0.05）。治疗前，两组患者FBG、TC、TG、LDL-C、HbA1c、SOD、MDA、GSH-PX水平及BMI比较，差异均无统计学意义（P＞0.05）；治疗后，两组患者上述指标均显著改善，且试验组明显优于对照组，差异有统计学意义（P＜0.05）。两组患者均未见明显不良反应发生。结论：复方黄连降糖散治疗FBG受损患者疗效显著，能明显改善患者各项实验室检查指标，且安全性较好。 |
| ABSTRACT： | OBJECTIVE： To observe clinical efficacy and safety of Compound huanglian jiangtang powder for patients with impaired fasting blood glucose（FBG）. METHODS： 122 patients with impaired FBG were selected and randomly divided into control group and trial group with 61 cases in each group. Two groups was given healthy education and diet guidance； trial group was given Compound huanglian jiangtang powder 2.5 g orally， qd. Both groups were treated for 4 months. Clinical efficacy of 2 groups was observed and FBG， TC， TG， LDL-C， HbA1c， SOD， MDA and GSH-PX levels and BMI were observed before and after treatment. The occurrence of ADR was recorded. RESULTS： Total effective rate of trial group was 77.0％， which was significantly higher than that of control group （24.6％）， with statistical significance （P＜0.05）. Before treatment， there was no statistical significance in FBG， TC， TG， LDL-C， HbA1c， SOD， MDA and GSH-PX levels and BMI between 2 groups （P＞0.05）； after treatment， above indexes of 2 groups were improved significantly， the trial group was significantly better than the control group， with statistical significance （P＜0.05）. No obvious ADR was found in 2 groups. CONCLUSIONS： Compound huanglian jiangtang powder is effective improvement of laboratory indexes and safe for impaired FBG. |
| 期刊： | 2016年第27卷第17期 |
| 作者： | 陈国超，李小莉，李莉萍 |
| AUTHORS： | CHEN Guochao，LI Xiaoli，LI Liping |
| 关键字： | 复方黄连降糖散；空腹血糖受损；疗效；安全性 |
| KEYWORDS： | Compound huanglian jiangtang powder； Impaired fasting blood glucose； Therapeutic efficacy； Safety |
| 阅读数： | 499 次 |
| 本月下载数： | 2 次 |
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