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舒血宁注射液辅助治疗创伤性蛛网膜下腔出血患者的临床观察
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| 篇名： | 舒血宁注射液辅助治疗创伤性蛛网膜下腔出血患者的临床观察 |
| TITLE： | |
| 摘要： | 目的：观察舒血宁注射液辅助治疗创伤性蛛网膜下腔出血患者的临床疗效及安全性。方法：将96例创伤性蛛网膜下腔出血患者按随机数字表法分为对照组和观察组，各48例。对照组患者给予氨甲环酸注射液、尼莫地平注射液和胞磷胆碱注射液进行常规治疗，每日行腰椎穿刺，测颅内压引流脑脊液；观察组患者在对照组基础上加用舒血宁注射液20 ml加入5％葡萄糖注射液250 ml中，ivgtt，qd。两组患者均连续治疗2周。观察两组患者的临床疗效及治疗前后格拉斯哥指数（GCS）评分、动脉血流速度（MCA）水平，并记录不良反应发生率。结果：观察组患者良好率（60.42％）显著高于对照组患者（31.25％），差异有统计学意义（P＜0.05）；治疗前及治疗后3、5 d，两组患者GCS评分、MCA比较，差异无统计学意义（P＞0.05）；治疗后7、14 d，两组患者GCS评分明显升高，MCA水平明显降低，且观察组明显优于对照组，差异有统计学意义（P＜0.05）；观察组患者脑血管痉挛、脑梗死和脑出血发生率分别为8.33％、4.17％和4.17％，对照组患者分别为16.67％、12.50％和16.67％，观察组明显低于对照组，差异有统计学意义（P＜0.05）。结论：舒血宁注射液辅助治疗创伤性蛛网膜下腔出血患者疗效显著，且不良反应发生率较低。 |
| ABSTRACT： | OBJECTIVE： To observe clinical efficacy and safety of Shuxuening injection in the adjunctive treatment of traumatic subarachnoid hemorrhage. METHODS： 96 patients with traumatic subarachnoid hemorrhage were randomly divided into control group and observation group with 48 patients in each group. Control group was given Tranexamic acid injection， Nimodipine injection and Citicoline injection， daily lumbar punctrive and determined intracranial pressure and drained cerebrospinal fluid via lumbar puncture； observation group was additionally given Shuxuening injection 20 ml added into 5％ Glucose injection 250 ml， ivgtt， qd. Both group were treated for consecutive 2 weeks. Clinical efficacy of 2 groups were observed， and GCS and MCA were also observed before and after treatment； ADR of 2 groups were recorded. RESULTS： Excellent rate of observation group （60.42％） was significantly higher than that of control group （31.25％）， with statistical significance （P＜0.05）. Before treatment， 3 and 5 days after treatment， there was no statistical significance in GCS and MCA between 2 groups （P＞0.05）； 7 and 14 days after treatment， GCS of 2 groups increased significantly while MCA decreased significantly， and the observation group was better than the control group， with statistical significance （P＜0.05）. The incidence of cerebral vasospasm， cerebral infarction and cerebral hemorrhage were 8.33％， 4.17％ and 4.17％ in observation group， and those of control group were 16.67％， 12.50％ and 16.67％； the observation group was significantly lower than the control group， with statistical significance （P＜0.05）. CONCLUSIONS： Shuxuening injection shows significant therapeutic efficacy in the adjunctive treatment of traumatic subarachnoid hemorrhage， with low incidence of ADR. |
| 期刊： | 2016年第27卷第17期 |
| 作者： | 彭智，艾文兵 |
| AUTHORS： | PENG Zhi，AI Wenbing |
| 关键字： | 舒血宁注射液；创伤性蛛网膜下腔出血；疗效；安全性 |
| KEYWORDS： | Shuxuening injection； Traumatic subarachnoid hemorrhage； Clinical efficacy； Safety |
| 阅读数： | 350 次 |
| 本月下载数： | 2 次 |
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