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柴胡舒肝散联合氯硝西泮治疗肝气郁结型焦虑症的临床观察
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| 篇名： | 柴胡舒肝散联合氯硝西泮治疗肝气郁结型焦虑症的临床观察 |
| TITLE： | |
| 摘要： | 目的：观察柴胡舒肝散联合氯硝西泮治疗肝气郁结型焦虑症的临床疗效及安全性。方法：选择肝气郁结型焦虑症患者96例，按随机数字表法分为观察组和对照组，各48例。对照组患者口服氯硝西泮片，起始剂量0.5 mg，逐渐加量至4.0 mg，tid；观察组患者在对照组基础上加服柴胡舒肝散水煎汁300 ml，bid。两组患者均治疗6周。观察两组患者临床疗效及治疗前后汉密尔顿焦虑量表（HAMA）、焦虑自评量表 （SAS）评分，并比较不良反应发生率。结果：观察组总有效率（97.92％）显著高于对照组（83.33％），差异有统计学意义（P＜0.05）。两组患者治疗前HAMA评分及SAS评分比较，差异无统计学意义（P＞0.05）；两组患者治疗后1、3、6周HAMA评分及SAS评分均显著降低，且观察组显著低于对照组，差异均有统计学意义（P＜0.05）。两组患者不良反应发生率比较，差异无统计学意义（P＞0.05）。结论：柴胡舒肝散联合氯硝西泮治疗肝气郁结型焦虑症疗效显著，能明显改善患者焦虑状态，且安全性良好。 |
| ABSTRACT： | OBJECTIVE： To observe clinical efficacy and safety of Chaihu shugan powder combined with clonazepam in the treatment of liver qi stagnation type anxiety. METHODS： 96 patients with liver qi stagnation type anxiety were randomly divided into observation group and control group， with 48 cases in each group. Control group was given Clonazepam tablet with initial dose of 0.5 mg， increasing to 4.0 mg gradually， tid； observation group was additionally given Chaihu shugan powder 300 ml， bid， on the basis of control group. Both groups were treated for 6 weeks. Clinical efficacy of 2 groups were observed， and HAMA and SAS were observed before and after treatment； the incidence of ADR were compared between 2 groups. RESULTS： The total effective rate of observation group （97.92％） was significantly higher than that of control group （83.33％）， with statistical significance （P＜0.05）. There was no statistical significance in HAMA and SAS between 2 groups before treatment （P＞0.05）； HAMA and SAS of 2 groups decreased significantly 1， 3 and 6 weeks after treatment， and the observation group was lower than the control group， with statistical significance （P＜0.05）. There was no statistical significance in the incidence of ADR between 2 groups （P＞0.05）. CONCLUSIONS： Chaihu shugan powder combined with clonazepam is effective， improve patient anxiety and safe in the treatment of liver qi stagnation type anxiety. |
| 期刊： | 2016年第27卷第17期 |
| 作者： | 程洪燕，梅妍，杜宏伟 |
| AUTHORS： | CHENG Hongyan，MEI Yan，DU Hongwei |
| 关键字： | 柴胡舒肝散；氯硝西泮；肝气郁结型焦虑症；疗效；安全性 |
| KEYWORDS： | Chaihu shugan powder； Clonazepam； Liver qi stagnation anxiety； Clinical efficacy； Safety |
| 阅读数： | 581 次 |
| 本月下载数： | 1 次 |
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