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生脉注射液对子宫切除术全身麻醉患者心肌功能的影响
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| 篇名： | 生脉注射液对子宫切除术全身麻醉患者心肌功能的影响 |
| TITLE： | |
| 摘要： | 目的：探讨生脉注射液对子宫切除术全身麻醉患者心肌功能的影响及安全性。方法：选取子宫切除术患者40例，按随机数字表法分为观察组和对照组，各20例。两组患者均采用枸橼酸芬太尼+罗库溴铵进行全身麻醉诱导，给予丙泊酚吸入麻醉。观察组患者麻醉前给予生脉注射液1 ml/kg，ivgtt；对照组患者麻醉前给予同等剂量0.9％氯化钠注射液，ivgtt。比较两组患者入室前（T0）、麻醉诱导前（T1）、插管时（T2）、术毕（T3）各时点的平均动脉压（MAP）、心率（HR）、中心静脉压（CVP）、血氧饱和度（SpO2），静脉血中丙二醛（MDA）、超氧化物歧化酶（SOD）及一氧化氮合酶（NOS）水平，并观察不良反应发生情况。结果：两组患者T0、T1时点MAP、HR比较，差异无统计学意义（P＞0.05）；观察组患者T2、T3时点MAP、HR显著高于对照组，差异有统计学意义（P＜0.05）。两组患者各时点CVP、SpO2比较，差异均无统计学意义（P＞0.05）。两组患者T0时点MDA、SOD、NOS水平比较，差异无统计学意义（P＞0.05）；T1、T2、T3时点两组患者MDA、NOS水平显著升高，SOD水平显著降低，且T1、T2时点观察组MDA、NOS水平显著低于对照组，SOD水平显著高于对照组，差异均有统计学意义（P＜0.05）。两组患者均未见明显不良反应发生。结论：生脉注射液能有效维持子宫切除术全身麻醉患者HR、MAP稳定，减少氧化物，从而保护心肌功能，且安全性较好。 |
| ABSTRACT： | OBJECTIVE： To investigate the effect and safety of Shengmai injection on myocardial function of patients with general anesthesia of hysterectomy. METHODS： 40 patients underwent hysterectomy were randomly divided into observation group and control group with 20 cases in each group. Both groups received general anesthesia induction of fentanyl citrate and rocuronium， and inhalation anesthesia of propofol. Observation group was given Shengmai injection 1 ml/kg，ivgtt；control group was given same dose of 0.9％ Sodium chloride injection， ivgtt， before anesthesia. Mean arterial pressure （MAP）， heart rate （HR）， central venous pressure （CVP）， blood oxygen saturation （SpO2）， the levels of MDA， SOD and NOS were compared between 2 groups before operation （T0）， before anesthesia induction （T1）， reaction during （T2）， after operation（T3）. The occurrence of ADR was also observed. RESULTS： There was no statistical significance in MAP and HR between 2 groups at T0 and T1 （P＞0.05）. ?MAP and HR of observation group was significantly higher than those of control group at T2 and T3， with statistical significance （P＜0.05）.There was no statistical significance in CVP and SpO2 between 2 groups at different time points （P＞0.05）. There was no statistical significance in MDA， SOD and NOS levels between 2 groups at T0 （P＞0.05）. MDA and NOS levels of 2 groups increased significantly at T1， T2 and T3， while SOD level decreased significantly； MDA and NOS level of observation group were lower than the control group while SOD level was higher than control group at T1， T2， with statistical significance （P＜0.05）. No obvious ADR was found in 2 groups. CONCLUSIONS： Shengmai injection can maintain stable HR and MAP， and reduce the oxide in patients underwent hysterectomy surgery so as to protect myocardial function with good safety. |
| 期刊： | 2016年第27卷第17期 |
| 作者： | 郝玉苓，沈啟云 |
| AUTHORS： | HAO Yuling，SHEN Qiyun |
| 关键字： | 生脉注射液；心肌功能；子宫切除术；全身麻醉 |
| KEYWORDS： | Shengmai injection； Myocardial function； Hysterectomy； General anesthesia |
| 阅读数： | 669 次 |
| 本月下载数： | 1 次 |
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