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阿奇霉素序贯疗法用于儿童支原体肺炎的临床观察
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| 篇名： | 阿奇霉素序贯疗法用于儿童支原体肺炎的临床观察 |
| TITLE： | |
| 摘要： | 目的：观察阿奇霉素序贯疗法用于儿童支原体肺炎的疗效和安全性。方法：67例支原体肺炎患儿随机分为对照组（34例）和观察组（33例）。两组患儿均给予退热、止咳等常规治疗，并辅以营养支持。在此基础上，对照组患儿给予注射用乳糖酸阿奇霉素10 mg/kg，加入5％葡萄糖注射液200 ml中，静脉滴注，每日1次；观察组患儿给予注射用乳糖酸阿奇霉素（用法用量同对照组）静脉滴注5 d后，改用阿奇霉素干混悬剂10 mg/（kg·d），口服，连用3 d后停4 d。两组疗程均为7～10 d。观察两组患儿的临床疗效，退热时间、咳嗽消失时间、肺部啰音消失时间，治疗前后肺功能指标及不良反应发生情况。结果：两组患儿总有效率、退热时间、咳嗽消失时间、肺部啰音消失时间比较，差异均无统计学意义（P＞0.05）。治疗后，两组患儿肺功能指标水平均显著高于同组治疗前，差异均有统计学意义（P＜0.01），但组间比较差异无统计学意义（P＞0.05）。观察组患儿不良反应发生率显著低于对照组，差异有统计学意义（P＜0.05）。结论： 在常规治疗的基础上， 阿奇霉素序贯治疗儿童支原体肺炎的疗效与未采用序贯疗法相当，但安全性优于未采用序贯疗法。 |
| ABSTRACT： | OBJECTIVE： To observe the efficacy and safety of azithromycin sequential therapy in the treatment of mycoplasma pneumonia in children. METHODS： 67 children with mycoplasma pneumonia were randomly divided into control group （34 cases） and observation group （33 cases）. All children received conventional treatment， such as fever， cough， supplemented by nutrition support； based on it， control group received 10 mg/kg Azithromycin for injection， adding into 5％ Glucose injection by intravenous drip in 200 ml， once a day； observation group received azithromycin （the same dosage with control group） after intravenous drip 5 d， switched to 10 mg/（kg·d） Azithromycin dry suspension， orally， then stopped 4 d after continuous 3 d. The treatment course was 7-10 d. Clinical efficacy， disappearance time of fever， cough and lung rales， and lung indexes before and after treatment， and the incidence of adverse reactions in 2 groups were observed. RESULTS： There were no significant differences in the total effective rate， disappearance time of fever， cough and lung rales in 2 groups （P＞0.05）. After treatment， the lung function indexes were significantly higher than before， the differences were statistically significant （P＜0.01）， but there was no significant difference between 2 groups （P＞0.05）. The incidence of adverse reactions in observation group was significantly lower than control group， the difference was statistically significant （P＜0.05）. CONCLUSIONS： Based on conventional treatment， azithromycin sequential therapy shows similar efficacy to without sequential therapy in the treatment of mycoplasma pneumonia in children， but with better safety. |
| 期刊： | 2016年第27卷第18期 |
| 作者： | 楚加元，许洲 |
| AUTHORS： | CHU Jiayuan，XU Zhou |
| 关键字： | 儿童；支原体肺炎；阿奇霉素；序贯疗法；疗效；安全性 |
| KEYWORDS： | Children； Mycoplasma pneumonia； Azithromycin； Sequential therapy； Efficacy； Safety |
| 阅读数： | 438 次 |
| 本月下载数： | 2 次 |
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