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康复新液治疗小儿手足口病的临床观察
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| 篇名： | 康复新液治疗小儿手足口病的临床观察 |
| TITLE： | |
| 摘要： | 目的：观察康复新液治疗小儿手足口病的临床疗效及安全性。方法：将128例手足口病患儿按随机数字表法分为观察组和对照组，各64例。对照组患儿给予皮肤疱疹及口腔护理，对血象升高提示感染患儿给予抗菌药物治疗，酌情应用补液及非甾体类解热镇痛药物等常规治疗。观察组患儿在对照组基础上口服康复新液，≤3岁者，3 ml，tid；＞3岁者，5 ml，tid。观察两组患儿临床疗效及治疗前后C反应蛋白（CRP）、乳酸、免疫球蛋白（Ig）和心肌酶水平，并比较两组患儿治疗后症状体征消失时间及不良反应。结果：观察组患儿总有效率（89.06％）显著高于对照组（70.31％），差异有统计学意义（P＜0.05）。两组患儿治疗前CRP、乳酸、Ig、心肌酶水平及治疗后IgM比较，差异均无统计学意义（P＞0.05）；两组患儿治疗后CRP、乳酸、肌酸磷酸酶及乳酸脱氢酶水平明显降低，IgA、IgG水平明显升高，且观察组显著高于对照组，差异均有统计学意义（P＜0.05）。观察组患儿退热时间、手足皮疹消退时间、口腔溃疡愈合时间均明显短于对照组，差异有统计学意义（P＜0.05）。两组患儿治疗期间均未见明显不良反应发生。结论：康复新液治疗小儿手足口病疗效显著，能明显改善患儿CRP、Ig、乳酸、心肌酶水平，且安全性较好。 |
| ABSTRACT： | OBJECTIVE： To observe clinical efficacy and safety of Kangfuxin liquid in the treatment of pediatric hand， foot and mouth disease. METHODS： 128 children with hand， foot and mouth disease were randomly divided into observation group and control group， with 64 cases in each group. Control group was given routine treatment as herpes and oral care， antibiotics for infective children reflected by hemogram elevation， fluid infusion and non-steroidal analgesic-antipyretic agent based on disease condition. Observation group was additionally given Kangfuxin liquid， 3 ml for below 3 year-old， tid and 5 ml for more than 3 year-old， tid. Clinical efficacy of 2 groups were observed as well as CRP， lactic acid， Ig， the level of myocardial enzyme before and after treatment； the time of symptoms and signs disappearance and ADR were compared between 2 groups after treatment. RESULTS： The total effective rate of observation group （89.06％） was significantly higher than that of control group （70.31％）， with statistical significance （P＜0.05）. There was no statistical significance in CRP， lactic acid， Ig and myocardial enzyme before treatment and IgM level after treatment between 2 groups， with statistical significance （P＞0.05）. CRP， lactic acid creatine kinase and lactate dehydrogenase level of 2 groups decreased significantly， while IgA and IgG levels increased significantly， and the observation group was higher than the control group， with statistical significance （P＜0.05）. Antipyretic time， hand foot skin rash subsided time and oral ulcer healing time of observation group were significantly shorter than those of control group， with statistical significance （P＜0.05）. No obvious ADR was found in 2 groups during treatment. CONCLUSIONS： Kangfuxin liquid is effective in the treatment of hand， foot and mouth disease in children， and can effectively improve CRP， Ig， lactic acid， and myocardial enzyme level with good safety. |
| 期刊： | 2016年第27卷第20期 |
| 作者： | 王勇，方红星，刘艳，刘惠敏，姬媛 |
| AUTHORS： | WANG Yong，FANG Hongxing，LIU Yan，LIU Huimin，JI Yuan |
| 关键字： | 康复新液；小儿手足口病；心肌酶谱；C反应蛋白；乳酸；免疫球蛋白 |
| KEYWORDS： | Kangfuxin liquid； Pediatric hand， foot and mouth disease； Myocardial enzyme； CRP； Lactic acid； Immune globulin |
| 阅读数： | 260 次 |
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