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黎药除湿祛风汤对鸡Ⅱ型胶原蛋白诱导关节炎模型大鼠的保护作用研究
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| 篇名： | 黎药除湿祛风汤对鸡Ⅱ型胶原蛋白诱导关节炎模型大鼠的保护作用研究 |
| TITLE： | |
| 摘要： | 目的：研究黎药除湿祛风汤对鸡Ⅱ型胶原蛋白诱导关节炎模型大鼠的保护作用。方法：将60只大鼠随机分为正常组、模型组、阳性组和除湿祛风汤高、中、低剂量组[45.9、22.95、11.48 g（生药）/kg]，除正常组外，其余各组大鼠均以鸡Ⅱ型胶原蛋白诱导关节炎模型。建模后，除湿祛风汤各剂量组大鼠ig相应药物，正常组和模型组大鼠ig生理盐水，每天1次，连续给药12 d；阳性组大鼠实验1～3 d ig来氟米特4.5 mg/kg，4～12 d ig来氟米特1.8 mg/kg，每天1次。观察大鼠关节病变程度并进行评分，测定关节肿胀度和血清中肿瘤坏死因子α（TNF-α）、白细胞介素1β（IL-1β）和Ⅱ型胶原蛋白抗体水平。结果：与正常组比较，模型组大鼠关节炎指数评分、关节肿胀度及血清中TNF-α、IL-1β、Ⅱ型胶原蛋白抗体水平显著升高（P＜0.01）。与模型组比较，阳性组和除湿祛风汤高剂量组大鼠病理评分显著降低，各给药组大鼠血清中TNF-α、IL-1β、Ⅱ型胶原蛋白抗体水平显著降低（P＜0.05或P＜0.01）。结论：黎药除湿祛风汤对鸡Ⅱ型胶原蛋白诱导模型大鼠具有一定的保护作用。 |
| ABSTRACT： | OBJECTIVE： To study the protective effects of Li medicine Chushi qufeng decoction on arthritis model rats. METHODS： 60 rats were randomly divided into normal group， model group， positive group and Chushi qufeng decoction high-dose， medium-dose and low-dose groups [45.9， 22.95， 11.48 g（crude drug）/kg]. Except for normal group， those groups were given chicken type Ⅱ collagen to induce arthritis model. After modeling， normal group and model group were given normal saline intragastrically， once a day， for consecutive 12 d； Chushi qufeng decoction groups were given relevant medicine intragastrically； positive group was given leflunomide 4.5 mg/kg on 1st-3rd day and 1.8 mg/kg on 4th-12th day. The degree of joint lesion in rats were scored. The degree of joint swelling was determined as well as the serum levels of TNF-α， IL-1β and type Ⅱ collagen antibody. RESULTS： Compared with normal group， arthritis index， degree of joint swelling， the serum levels of TNF-α， IL-1β and type Ⅱ collagen antibody increased significantly in model group （P＜0.01）. Compared with model group， pathological score of positive group and Chushi qufeng decoction high-dose group decreased significantly， and serum levels of TNF-α， IL-1β and type Ⅱ collagen antibody decreased significantly in treatment groups （P＜0.05 or P＜0.01）. CONCLUSIONS： Li medicine Chushi qufeng decoction has certain protective effect on arthritis model rats induced by chicken type Ⅱ collagen. |
| 期刊： | 2016年第27卷第22期 |
| 作者： | 张丽，张一云，符洪，王开裕，雷玲芳，王春桃 |
| AUTHORS： | ZHANG Li，ZHANG Yiyun，FU Hong，WANG Kaiyu，LEI Lingfang，WANG Chuntao |
| 关键字： | 黎药；除湿祛风汤；类风湿性关节炎；肿瘤坏死因子α；白细胞介素1β；大鼠 |
| KEYWORDS： | Li medicine； Chushi qufeng decoction； Rheumatoid arthritis； TNF-α； IL-1β； Rat |
| 阅读数： | 283 次 |
| 本月下载数： | 2 次 |
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