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头孢唑肟致溶血性贫血的文献分析
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| 篇名： | 头孢唑肟致溶血性贫血的文献分析 |
| TITLE： | |
| 摘要： | 目的：了解头孢唑肟引起溶血性贫血的相关情况，为临床预防和诊治头孢唑肟所致溶血性贫血提供依据。方法：以“头孢唑肟”“溶血”“Ceftizoxime”“Hemolysis”等为关键词检索中国知网、万方、PubMed数据库1986－2015年的相关文献，统计各文献报道的发生头孢唑肟致溶血性贫血患者的一般情况、临床用药及表现、发生时间及转归等，分析其发生机制，提出预防和治疗措施。结果与结论：共检索到相关文献11篇，其中国外4篇，国内7篇；病例共计15例，国外5例，国内10例；按年龄分婴幼儿7例、老年人4例、中年人3例、青年1例；发生时间多为输注头孢唑肟的第2～7天（8例）；大部分患者经过治疗后好转，3例患者经救治后死亡。该反应发生机制主要包括免疫复合物产生和非免疫性蛋白吸附2种。建议在应用头孢唑肟前应详细了解患者的变态反应史、重视皮肤敏感试验、选择适宜的剂量并避免与其他药物联用；在使用过程中应严密监护患者的用药情况，一旦发生溶血性贫血应立即停用药物，并相应采取激素治疗、综合治疗、输血治疗等措施，避免危及患者生命安全。 |
| ABSTRACT： | OBJECTIVE： To provide reference for clinical prevention and treatment of ceftizoxime-induced hemolytic anemia by investigating the situation of ceftizoxime-induced hemolytic anemia. METHODS： Using Chinese and English “ceftizoxime”“hemolysis” and other words as key words， related literatures during 1986-2015 were retrieved from CNKI， Wanfang database and PubMed database. Those literatures were analyzed statistically in respects of general information， clinical drug use and manifestation， occurrence time and outcome， etc. The mechanisms of hemolytic anemia were analyzed to put forward prevention and treatment measures. RESULTS & CONCLUSIONS： A total of 11 literatures were retrieved， including 4 foreign literatures and 7 domestic ones. There were 15 cases in total， including 5 foreign cases and 10 domestic cases. According to the patient’s age， there were 7 cases of infants， 4 cases of the elderly， 3 cases of middle-aged people and 1 case of youth. The hemolytic anemia often occurred on the 2-7 day （8 cases）. Most of the patients were improved after treatment， but there were 3 patients who died. The mechanism of hemolytic anemia mainly included the production of immune complex and non-immunologic protein adsorption. It is suggested to investigate allergic reaction history， pay attention to sensitization test on skin， select suitable drug dosage and avoid drug combination. The patient’s medications should be monitored closely. Once hemolytic anemia occurs， it should be immediately stop using the drug and take appropriate measures as hormone treatment， comprehensive treatment， blood transfusion treatment， to avoid endangering the life safety of patients. |
| 期刊： | 2016年第27卷第25期 |
| 作者： | 樊王冬，陈丹镝，周家青，江莉 |
| AUTHORS： | FAN Wangdong，CHEN Dandi，ZHOU Jiaqing，JIANG Li |
| 关键字： | 头孢唑肟；溶血性贫血；文献分析；机制 |
| KEYWORDS： | Ceftizoxime； Hemolytic anemia； Literature analysis； Mechanism |
| 阅读数： | 371 次 |
| 本月下载数： | 5 次 |
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