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黄芪注射液联合沙美特罗替卡松粉吸入剂对COPD患者肺功能、细胞因子和血液流变学指标的影响
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| 篇名： | 黄芪注射液联合沙美特罗替卡松粉吸入剂对COPD患者肺功能、细胞因子和血液流变学指标的影响 |
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| 摘要： | 目的：探讨黄芪注射液联合沙美特罗替卡松粉吸入剂对慢性阻塞性肺疾病（COPD）患者肺功能、细胞因子、血液流变学指标的影响。方法：104例COPD患者按照随机数字表法分为观察组和对照组，各52例。对照组患者给予常规对症治疗+沙美特罗替卡松粉吸入剂1吸，bid，观察组患者在对照组基础上给予黄芪注射液30 ml加入5％葡萄糖注射液250 ml中，ivgtt，qd。两组患者疗程均为2周。观察两组患者临床疗效、肺功能指标[一秒用力呼气容积（FEV1）、用力肺活量（FVC）、FEV1/FVC]、C反应蛋白（CRP）、细胞因子[白细胞介素（IL）6、IL-8、肿瘤坏死因子（TNF）α]水平、血液流变学指标（全血高切黏度、全血低切黏度、纤维蛋白原、血细胞比容和血浆黏度）和不良反应发生情况。结果：观察组患者总有效率（94.23％）明显高于对照组（75.00％）；两组患者治疗后的FEV1、FVC、FEV1/FVC均较治疗前明显升高，且观察组患者明显高于对照组；两组患者治疗后的CRP、IL-6、IL-8、TNF-α均较治疗前明显降低，且观察组患者明显低于对照组；观察组患者治疗后的全血高切黏度、全血低切黏度、纤维蛋白原、血细胞比容和血浆黏度均较治疗前明显降低，且观察组患者明显低于对照组，差异均有统计学意义（P＜0.05）。两组患者均未见明显不良反应发生。结论：黄芪注射液联合沙美特罗替卡松粉吸入剂治疗COPD疗效显著，可提高患者肺功能，改善微炎症状态，降低血液流变学指标水平，且安全性较好。 |
| ABSTRACT： | OBJECTIVE： To investigate the effects of Astragalus injection combined with Salmeterol propionate powder inhalation on pulmonary function， cytokines and blood rheology indexes of Chronic obsrnctine pulmonary disease （COPD） patients. METHODS： 104 COPD patients were divided into observation group and control group according to the randorn number table method， with 52 cases in each group. Control group was given routine symptomatic treatment+Salmeterol propionate powder inhalation 1 dose， bid； observation group was additionally given Astragalus injection 30 ml added into 5％ Glucose injection 250 ml， ivgtt， qd， on the basis of control group. Treatment course of 2 groups lasted for 2 weeks. Clinical efficacy， pulmonary function indexes [forced expiratory volume in one second （FEV1）， forced vital capacity （FVC）， FEV1/FVC]， CRP， cytokine [IL-6， IL-8， TNF-α] levels， blood rheology indexes （whole blood high-shear viscosity， whole blood low-shear viscosity， fibrinogen， hematokrit and plasma viscosity）， and the occurrence of ADR were observed in 2 groups. RESULTS： The total effective rate of observation group （94.23％） was significantly higher than that of control group （75.00％）； compared with before treatment， FEV1， FVC and FEV1/FVC of 2 groups were significantly increased after treatment， and those of observation group were significantly higher than those of control group； CRP， IL-6， IL-8 and TNF-α of 2 groups were significantly decreased， and those of observation group were significantly lower than those of control group. The whole blood high-shear viscosity， whole blood low-shear viscosity， fibrinogen， hematocrit and plasma viscosity of observation group were decreased significantly after treatment， and the observation group was significantly lower than the control group， with statistical significance （P＜0.05）. No significant ADR was found in 2 groups. CONCLUSIONS： Astragalus injection combined with Salmeterol propionate powder inhalation is significantly effective for COPD， improves pulmonary function of patients， improves micro inflammatory state and decreases blood rheology indexes with good safety. |
| 期刊： | 2016年第27卷第26期 |
| 作者： | 徐翠容，贾坤林，钟晓莉，余丹，高青，李红平，李林玉 |
| AUTHORS： | XU Cuirong，JIA Kunlin，ZHONG Xiaoli，YU Dan，GAO Qing，LI Hongping，LI Linyu |
| 关键字： | 黄芪注射液；沙美特罗替卡松粉吸入剂；慢性阻塞性肺疾病；疗效；肺功能；细胞因子；血液流变学 |
| KEYWORDS： | Astragalus injection； Salmeterol propionate powder inhalation； Chronic obstuctive pulmonary disease； Therapeutic efficacy； Pulmonary function； Cytokine； Blood rheology |
| 阅读数： | 265 次 |
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