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大剂量伐昔洛韦联合针刺治疗带状疱疹的临床观察
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| 篇名： | 大剂量伐昔洛韦联合针刺治疗带状疱疹的临床观察 |
| TITLE： | |
| 摘要： | 目的：探讨大剂量伐昔洛韦联合针刺治疗带状疱疹的临床疗效及安全性。方法：将194例带状疱疹患者按随机数字表法分为对照组和观察组，各97例。对照组患者给予针刺治疗；观察组患者在对照组基础上加服盐酸伐昔洛韦片0.3 g，bid。两组患者均治疗10 d。观察两组患者临床疗效、临床症状改善时间及治疗前后视觉模拟（VAS）评分、P物质水平，并观察后遗神经痛和不良反应发生情况。结果：观察组患者总有效率为97.9％，明显高于对照组的90.7％ ，差异有统计学意义（P＜0.05）；观察组患者止痛、止疱、皮损结痂、皮损消失时间均明显短于对照组，差异均有统计学意义（P＜0.05）。两组患者治疗前VAS评分及P物质水平比较，差异无统计学意义（P＞0.05）；治疗后，两组患者VAS评分及P物质水平显著降低，且观察组低于对照组，差异均有统计学意义（P＜0.05）。观察组患者后遗神经痛发生率为14.4％ ，显著低于对照组的28.9％，差异有统计学意义（P＜0.05）。两组患者不良反应发生率比较，差异无统计学意义（P＞0.05）。结论：大剂量伐昔洛韦联合针刺治疗带状疱疹疗效显著，具有止痛、促进皮损恢复、后遗神经痛发生率低等优点，且安全性较好。 |
| ABSTRACT： | OBJECTIVE： To investigate the clinical efficacy and safety of high-dose valaciclovir combined with acupuncture in the treatment of herpes zoster. METHODS： 194 patients with herpes zoster were divided into control group and observation group according to random number table method， with 97 cases in each group. Control group was given acupuncture treatment； observation group was additionally given Valaciclovir hydrochlordide tablet 0.3 g， bid， based on control group. Both group received treatment for 10 d. Clinical efficacy and the time of clinical symptoms improvement were observed in 2 groups as well as VAS score and substance P level before and after treatment. The occurrence of postherpetic neuralgia and ADR were also observed in 2 groups. RESULTS： Total effective rate of observation group was 97.9％， which was significantly higher than 90.7％ of control group， with statistical significance （P＜0.05）. The analgesic time， stopping herpes time， lesion scabby time， lesion disappeared time of observation group were significantly shorter than those of control group， with statistical significance （P＜0.05）. There was no statistical significance in VAS score and substance P level between 2 groups before treatment （P＞0.05）； those of 2 groups were decreased significantly after treatment， and the observation group was lower than the control group， with statistical significance （P＜0.05）. The incidence of postherpetic neuralgia in observation group was 14.4％， which was significantly lower than 28.9％ of control group， with significant difference （P＜0.05）. There was no statistical significance in the incidence of ADR between 2 groups （P＞0.05）. CONCLUSIONS： High-dose valacyclovir combined with acupuncture can effectively treat herpes zoster， with advantages of analgesic effect， rapid lesions recovery， low rate of postherpetic neuralgia with good safety. |
| 期刊： | 2016年第27卷第26期 |
| 作者： | 周碧海，李建 |
| AUTHORS： | ZHOU Bihai，LI Jian |
| 关键字： | 针刺；伐昔洛韦；大剂量；带状疱疹；临床疗效；后遗神经痛 |
| KEYWORDS： | Acupuncture； Valaciclovir； High-dose； Herpes zoster； Clinical efficacy； Postherpetic neuralgia |
| 阅读数： | 400 次 |
| 本月下载数： | 3 次 |
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