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腹腔镜切除术后应用桂枝茯苓胶囊联合醋酸亮丙瑞林治疗子宫内膜异位症的临床观察
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| 篇名： | 腹腔镜切除术后应用桂枝茯苓胶囊联合醋酸亮丙瑞林治疗子宫内膜异位症的临床观察 |
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| 摘要： | 目的：观察腹腔镜切除术后应用桂枝茯苓胶囊联合醋酸亮丙瑞林治疗子宫内膜异位症（EMS）的疗效和安全性。方法：87例EMS患者随机分为对照组（44例）和观察组（43例）。对照组患者行腹腔镜切除术，术后第1次月经来潮后第1天给予注射用醋酸亮丙瑞林3.75 mg，肌内注射，每日1次。观察组患者在对照组治疗的基础上口服桂枝茯苓胶囊0.93 g，每日3次。两组疗程均为6个月。观察两组患者的临床疗效，治疗前后雌二醇（E2）、卵泡刺激素（FSH）、黄体生成素 （LH）和催乳素（PRL）水平，治疗6个月后的复发情况及不良反应发生情况。结果：观察组患者总有效率显著高于对照组，复发率显著低于对照组，差异均有统计学意义（P＜0.05）。治疗前，两组患者E2、FSH、LH、PRL比较，差异均无统计学意义（P＞0.05）。治疗后，两组患者E2、FSH、LH、PRL均显著低于同组治疗前，且观察组E2、FSH、LH低于对照组，差异均有统计学意义（P＜0.05）； 但两组患者PRL比较差异无统计学意义（P＞0.05）。两组患者不良反应发生率比较差异无统计学意义（P＞0.05）。结论：腹腔镜切除术后，桂枝茯苓联合醋酸亮丙瑞林治疗EMS，可显著提高疗效，降低患者性激素水平及复发率，且不增加不良反应的发生。 |
| ABSTRACT： | To observe the efficacy and safety of Guizhi fuling capsule combined with leuprolide acetate in the treatment of endometriosis （EMS） after laparoscopicsurgery. METHODS： 87 EMS patients were randomly divided into control group （44 cases） and observation group （43 cases）. Control group received EMS resection under laparoscope， 3.75 mg Leuprolide acetate for injection was given in the first day of postoperative first menstruation by intramuscular injection， once a day. Observation group additionally received 0.93 g Guizhi fuling capsule， 3 times a day. The treatment course for both groups was 6 months. Clinical efficacy， estradiol （E2）， follicle stimulating hormone （FSH）， luteinizing hormone （LH） and prolactin （PRL） levels before and after treatment， recurrence after 6 months and the incidence of adverse reactions in 2 groups were observed. RESULTS： The total effective rate in observation group was significantly higher than control group， recurrence rate was significantly lower than control group， the differences were statistically significant （P＜0.05）. Before treatment， there were no significant differences in E2， FSH， LH and PRL in 2 groups （P＞0.05）； after treatment， E2， FSH， LH and PRL in 2 groups were significantly lower than before， and E2， FSH and LH in observation group were lower than control group， the differences were statistically significant （P＜0.05）， but there was no significant difference in PRL in 2 groups （P＞0.05）. And there was no significant difference in the incidence of adverse reactions in 2 groups （P＞0.05）. CONCLUSIONS： After laparoscope resection， Guizhi fuling capsule combined with leuprolide acetate can effectively improve efficacy， reduce sex hormone level and recurrence rate， and do not increase the incidence of adverse reactions in the treatment of EMS. |
| 期刊： | 2016年第27卷第27期 |
| 作者： | 李彩辉，朱慧芳，翟悦静，刘秋杨 |
| AUTHORS： | LI Caihui，ZHU Huifang，ZHAI Yuejing，LIU Qiuyang |
| 关键字： | 腹腔镜切除术；桂枝茯苓胶囊；醋酸亮丙瑞林；子宫内膜异位症；疗效；安全性 |
| KEYWORDS： | Laparoscopicsurgery； Guizhi fuling capsule； Leuprolide acetate； Endometriosis； Efficacy； Safety |
| 阅读数： | 412 次 |
| 本月下载数： | 5 次 |
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