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非线性建模红外光谱法测定对乙酰氨基酚原料药的含量
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| 篇名： | 非线性建模红外光谱法测定对乙酰氨基酚原料药的含量 |
| TITLE： | |
| 摘要： | 目的：为利用红外光谱法进行对乙酰氨基酚无损检测提供理论依据。方法：准确称取0.002～0.02 g的对乙酰氨基酚原料药，分别加入0.2 g的溴化钾，充分研磨并混合均匀，采用溴化钾压片法配制成待测供试品。光源使用空心阴极灯，扫描频次为30次，分辨率0.5 cm－1，扫描范围4 000～400 cm－1，测定并记录红外吸收光谱，对药物的特征吸收峰进行筛选，从而确定最佳的特征吸收峰。运用数学建模方法分别建立线性模型和非线性模型。结果：本试验选择用吸光强度较弱但特征性较强的1 016 cm－1吸收峰进行分析。通过建立模型并进行计算可知，非线性模型检测的准确性远高于线性模型检测的准确性，非线性模型方程的r＝0.942。结论：非线性建模红外光谱法测定对乙酰氨基酚原料药含量是可行的，其适用于对乙酰氨基酚的无损、快速在线质量控制。 |
| ABSTRACT： | OBJECTIVE： To provide theoretical basis for the detection of paracetamol by infrared spectroscopy. METHODS： 0.002-0.02 g paracetamol was accurately weighed， added into 0.2 g potassium bromide， respectively， fully ground and well mixed， potassium bromide pressing plate method was used for to-be-tested test sample. Using hollow cathode lamp as light， scanning frequency was 30 times， resolution was 0.5 cm－1， scan range was 4000-400 cm－1， infrared absorption spectrum was determined and recorded to select the characteristic absorption peaks， then determine the optimized characteristic absorption peaks. Linear and nonlinear models were respectively established by using mathematics modeling methods. RESULTS：1 016 cm－1 absorption peak with weaker absorbance but stronger features was selected for the analysis. According to the model establishing and calculation， the accuracy of the nonlinear model was much higher than the linear model，r＝0.942. CONCLUSIONS： Nonlinear quantitative model for quantitatively determining the content of paracetamol is feasible， and suitable for the on-destructive and rapid on-line quality control of paracetamol. |
| 期刊： | 2016年第27卷第27期 |
| 作者： | 裘兰兰，李明梅 |
| AUTHORS： | QIU Lanlan，LI Mingmei |
| 关键字： | 对乙酰氨基酚；非线性模型；红外光谱法；含量测定 |
| KEYWORDS： | Paracetamol； Nonlinear model； Infrared spectrum； Content determination |
| 阅读数： | 989 次 |
| 本月下载数： | 3 次 |
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