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退白颗粒联合窄谱中波紫外线照射治疗寻常型白癜风的疗效观察
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| 篇名： | 退白颗粒联合窄谱中波紫外线照射治疗寻常型白癜风的疗效观察 |
| TITLE： | |
| 摘要： | 目的：观察退白颗粒联合窄谱中波紫外线（NB-UVB）照射治疗寻常型白癜风的临床疗效及对外周血细胞间黏附分子（ICAM-1）和趋化因子9（CXCL9）的影响。方法：选取寻常型白癜风患者60例，给予中药退白颗粒1剂加开水200 ml溶解后冲服，早晚各100 ml，联合NB-UVB皮损局部照射治疗，疗程为3个月。另选健康志愿者30例作为对照。观察不同分期、皮损面积、病程患者的临床疗效及治疗前后血清ICAM-1和CXCL9水平，并与健康志愿者比较。结果：进展期、皮损面积＜5％、病程＜1年患者临床总有效率分别为88.24％、87.10％、87.50％，显著高于稳定期的61.54％，皮损面积≥5％的65.52％及病程≥1年的64.29％，差异均有统计学意义（P＜0.05）。治疗前，所有分型患者ICAM-1和CXCL9水平均高于健康对照组，且进展期患者高于稳定期，皮损面积≥5％者高于＜5％者、病程＜1年者高于≥1年者，差异均有统计学意义（P＜0.05）；治疗后，除稳定期外，其他分型患者ICAM-1和CXCL9水平均显著低于治疗前，差异均有统计学意义（P＜0.05）。结论：退白颗粒联合NB-UVB照射治疗寻常型白癜风疗效较好，且可降低ICAM-1和CXCL9表达水平。 |
| ABSTRACT： | OBJECTIVE： To observe the clinical efficacy of Tuibai granules combined with narrow band UVB （NB-UVB） radiation in the treatment of vitiligo vulgaris and their effects on ICAM-1 and CXCL9 of peripheral blood. METHODS： 60 patients with vitiligo vulgaris were selected and treated with Tuibai granules dissloved in 200 ml water， orally， combined with NB-UVB local radiation for 3 months. Another 30 healthy volunteers were chosen as control group. Clinical efficacies of different stage， different skin lesion areas and different disease courses were observed as well as the serum levels of ICAM-1 and CXCL9 before and after treatment， which were compared with control group. RESULTS： Total effective rates of patients were 88.24％ in progressive stage， 87.10％ in those with skin lesion areas ＜5％ and 87.50％ in those with disease course＜1 year， which were significantly higher than 61.54％ in stable stage， 65.52％ in those with skin lesion area ≥5％ and 64.29％ in those with disease course ≥1 year， with statistical significance （P＜0.05）. Before treatment， the levels of ICAM-1 and CXCL9 in all kinds of patients were all higher than in healthy control group； those of progressive stage were higher than those of stable stage； those of skin lesion area ≥5％ was higher than those of skin lesion area＜5％； those of disease course＜1 year was higher than those of disease course ≥1 year， with statistical significance （P＜0.05）. After treatment， the levels of ICAM-1 and CXCL9 in all kinds of patients were significantly lower than before except for those in stable stage， with statistical significance （P＜0.05）. CONCLUSIONS： Tuibai granules combined with NB-UVB radiation shows good therapeutic efficacy in the treatment of vitiligo vulgaris， and can reduce the expression of ICAM-1 and CXCL9. |
| 期刊： | 2016年第27卷第32期 |
| 作者： | 盛国荣，蒋丽，谢勇，赵婧 |
| AUTHORS： | SHENG Guorong，JIANG Li，XIE Yong，ZHAO Jing |
| 关键字： | 寻常型白癜风；退白颗粒；黏附分子；趋化因子；疗效 |
| KEYWORDS： | Vitiligo vulgaris； Tuibai granules； ICAM-1；CXCL9； Clinical efficacy |
| 阅读数： | 290 次 |
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