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醋酸奥曲肽用于小儿急腹症术后的疗效观察
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| 篇名： | 醋酸奥曲肽用于小儿急腹症术后的疗效观察 |
| TITLE： | |
| 摘要： | 目的：观察醋酸奥曲肽用于小儿急腹症患儿术后的疗效及安全性。方法：选择急腹症患儿130例，按照随机数字表法分为观察组和对照组，各65例。对照组患儿术后给予注射用头孢曲松钠50 mg/kg，iv，qd，以及维持水电解质平衡；观察组患儿在对照组基础上采用微泵持续给予醋酸奥曲肽注射液0.01 mg/（kg·d），ivgtt（术后即刻），1～3 d。观察两组患儿腹内压、胃肠功能恢复时间、肿瘤坏死因子α（TNF-α）水平、肝/肾功能指标、血/尿淀粉酶水平，并记录不良反应发生情况。结果：观察组患儿的总有效率（98.5％）明显高于对照组（92.3％），差异有统计学意义（P＜0.05）。术后第3、5天，两组患儿腹内压、TNF-α、血/尿淀粉酶水平均较术前明显降低，且观察组患儿明显低于对照组，胃肠功能恢复时间亦明显短于对照组，差异均有统计学意义（P＜0.05）。手术前后，两组患儿的肝、肾功能指标比较，差异均无统计学意义（P＞0.05）。两组患儿治疗过程中均未见明显不良反应发生。结论：醋酸奥曲肽用于小儿急腹症术后可有效降低患儿腹内压、TNF-α、血/尿淀粉酶水平，改善胃肠功能，且安全性较高。 |
| ABSTRACT： | OBJECTIVE： To observe the effects and safety of octreotide acetate after pediatric acute abdomen surgery. METHODS： 130 children with acute abdomen were selected and randomly divided into observation group and control group， with 65 cases in each group. Control group was given Ceftriaxone sodium for injetion 50 mg/kg， iv， qd； after surgery to maintain water-electrolyte balance. Observation group was additionally given continuous pump of Octreotide acetate injection 0.01 mg/（kg·d），ivgtt （immediately after surgery）， for 1-3 d， on the basis of control group. The intra-abdominal pressure， the time of gastrointestinal function recovery， TNF-α level， liver/renal function index and blood/urine amylase were observed in 2 groups， and the occurrence of ADR was recorded. RESULTS： The total effective rate of observation group （98.5％） was significantly higher than that of control group （92.3％）， with statistical significance （P＜0.05）. On 3rd and 5th day after surgery， intra-abdominal pressure， the levels of TNF-α and blood/urine amylase were decreased significantly， compared to before surgery； the indexes of observation group were lower than that of control group， and the recovery of gastrointestinal function in observation group was significantly better than in control group， with statistical significance （P＜0.05）. There was no statistical significance in liver and renal function indexes between 2 groups before and after surgery （P＞0.05）. No obvious ADR was found in 2 groups during treatment. CONCLUSIONS： For pediatric acute abdomen， octreotide acetate can effectively reduce intra-abdominal pressure， the levels of TNF-α and blood/urine amylase， and improve gastrointestinal function with good safety |
| 期刊： | 2016年第27卷第32期 |
| 作者： | 杨广承，王玉红，徐晓青，邹大军，魏炜 |
| AUTHORS： | YANG Guangcheng，WANG Yuhong，XU Xiaoqing，ZOU Dajun，WEI Wei |
| 关键字： | 醋酸奥曲肽注射液；小儿急腹症；腹内压；淀粉酶；肿瘤坏死因子；肝功能；肾功能；胃肠功能 |
| KEYWORDS： | Octreotide acetate injection； Pediatric acute abdomen； Intra-abdominal pressure； Amylase； TNF； Liver function； Reral funclion； Gastrointest-inal function |
| 阅读数： | 263 次 |
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