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富马酸酮替芬联合孟鲁司特钠治疗儿童咳嗽变异性哮喘的临床观察
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| 篇名： | 富马酸酮替芬联合孟鲁司特钠治疗儿童咳嗽变异性哮喘的临床观察 |
| TITLE： | |
| 摘要： | 目的：观察富马酸酮替芬联合孟鲁司特钠治疗儿童咳嗽变异性哮喘（CVA）的临床疗效及安全性。方法：选取CVA患儿110例，按治疗方案分为观察组与对照组，各55例。对照组患儿给予孟鲁司特钠片5 mg，qd；观察组患儿在对照组基础上加用富马酸酮替芬片1 mg，bid。两组患儿均治疗3个月。观察两组患儿的临床疗效及治疗前后咳嗽症状评分和肺功能指标，并比较不良反应发生情况。结果：观察组患儿临床总有效率为92.73％，显著高于对照组的76.36％，差异有统计学意义（P＜0.05）。治疗前，两组患儿日间与夜间咳嗽症状评分、肺功能指标比较，差异无统计学意义（P＞0.05）；治疗后，两组患儿日间与夜间咳嗽症状评分、肺功能指标均显著改善，且观察组明显优于对照组，差异有统计学意义（P＜0.05）。两组患儿不良反应发生率比较，差异无统计学意义（P＞0.05）。结论：富马酸酮替芬联合孟鲁司特钠治疗儿童CVA较单独使用孟鲁司特钠疗效较好，能有效改善患儿咳嗽症状和肺功能，且不良反应未增加。 |
| ABSTRACT： | OBJECTIVE： To observe clinical efficacy and safety of ketotifen fumarate combined with montelukast sodium in the treatment of pediatric cough variant asthma （CVA）. METHODS： 110 children with CVA were selected and divided into observation group and control group according to therapy plan， with 55 cases in each group. Control group was given Montelukast sodium tablet 5 mg， qd； observation group was additionally given Ketotifen fumarate tablet 1 mg， bid. Both group received treatment for 3 months. Clinical efficacies of 2 groups were observed as well as cough symptom scores， lung function index before and after treatment. The occurrence of ADR was compared. RESULTS： The total effective rate of observation group was 92.73％， which was significantly higher than 76.36％ of control group， with statistical significance （P＜0.05）. Before treatment， there was no statistical significance in daytime and nighttime cough symptom scores， lung function index （P＞0.05）. After treatment， daytime and nighttime cough symptom scores， lung function index of 2 groups were improved significantly， and the observation group was significantly better than the control group， with statistical significance （P＜0.05）. There was no statistical significance in the incidence of ADR between 2 groups （P＞0.05）. CONCLUSIONS： Ketotifen fumarate combined with montelukast sodium is better than montelukast sodium in the treatment of pediatric CVA， can effectively improve cough symptom and lung function symptom and don’t increase the occurrence of ADR. |
| 期刊： | 2016年第27卷第32期 |
| 作者： | 杨丽丽，顾东明，俞杰，倪海东，李敏敏 |
| AUTHORS： | YANG Lili，GU Dongming，YU Jie，NI Haidong，LI Minmin |
| 关键字： | 富马酸酮替芬；孟鲁司特钠；咳嗽变异性哮喘；疗效；肺功能 |
| KEYWORDS： | Ketotifen fumarate； Montelukast sodium； Cough variant asthma； Efficacy； Lung funetion |
| 阅读数： | 932 次 |
| 本月下载数： | 6 次 |
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