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血必净注射液辅助治疗重症急性胰腺炎的临床观察
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| 篇名： | 血必净注射液辅助治疗重症急性胰腺炎的临床观察 |
| TITLE： | |
| 摘要： | 目的：探讨血必净注射液辅助治疗重症急性胰腺炎（SAP）的临床疗效及安全性。方法：选取SAP患者90例，按随机数字表法分为对照组和观察组，各45例。对照组患者给予营养支持、留置胃管、抗菌药物以及持续血液灌流等常规治疗。观察组患者在对照组的基础上给予血必净注射液100 ml，bid。两组患者均治疗7 d。观察两组患者血淀粉酶、腹痛、体温异常、腹胀、恶心呕吐、白细胞改善时间及并发症发生率，比较两组的临床疗效和不良反应发生情况。结果：观察组患者血淀粉酶、腹痛、体温异常、腹胀、恶心呕吐、白细胞改善时间均显著短于对照组，并发症发生率显著低于对照组（17.78％ vs. 64.44％），临床总有效率显著高于对照组（91.11％ vs. 73.33％），差异均有统计学意义（P＜0.05）。观察组有2例患者出现头痛、恶心，对照组患者未见明显不良反应发生。结论：血必净注射液辅助治疗SAP疗效显著，患者康复较快且并发症的发生率低，安全性较好。 |
| ABSTRACT： | OBJECTIVE： To investigate the clinical efficacy and safety of Xuebijing injection in adjunctive therapy of severe acute pancreatitis （SAP）. METHODS： 90 patients with SAP were selected and divided into control group and observation group according to random number table， with 45 cases in each group. Control group was given routine treatment as nutritional support， detaining gastric tube， antibiotics， continuous blood perfusion， etc. Observation group was additionally given Xuebijing injection 100 ml，bid， on the basis of control group. Both group received treatment for 7 d. The improvement time of blood amylase， abdominal pain， body temperature， abdominal distension， nausea and vomiting， and white blood cells， the incidence of complications， clinical efficacy as well as the occurrence of ADR were compare between 2 groups. RESULTS： The improvement time of blood amylase， abdominal pain， body temperature， abdominal distension， nausea and vomiting， white blood cells in observation group were significantly shorter than in control group； the incidence of compliance was significantly lower than control group（17.78％ vs. 64.44％）， while total effective rate was significantly higher than control group（91.11％ vs. 73.33％）， with statistical significance （P＜0.05）. 2 patients suffered from headache and nausea in observation group， and no obvious ADR was found in control group. CONCLUSIONS： Xuebijing injection is effective for adjunctive therapy of SAP with good safety； the patients recover quickly and the incidence of complications was in low level. |
| 期刊： | 2016年第27卷第32期 |
| 作者： | 黄鹏，黄寨，秦文波，陆政，莫祖聪 |
| AUTHORS： | HUANG Peng，HUANG Zhai，QIN Wenbo，LU Zheng，MO Zucong |
| 关键字： | 血必净注射液；重症急性胰腺炎；临床疗效；并发症 |
| KEYWORDS： | Xuebijing injection； Severe acute pancreatitis； Clinical efficacy； Compliance |
| 阅读数： | 967 次 |
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