我院114例严重的药品不良反应分析
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篇名: 我院114例严重的药品不良反应分析
TITLE:
摘要: 目的:了解精神专科医院严重的药品不良反应(ADR)的特点,为临床有效、安全用药提供参考。方法:回顾性分析我院2004-2015年114例严重的ADR,对患者一般情况、原患疾病、给药途径、剂型、药品种类、ADR累及器官/系统及临床表现、引起ADR最多的前5种药品及主要临床表现等进行统计分析。结果:114例严重的ADR中,女性患者多于男性(71/43);患者年龄主要集中在21~30岁(35例,30.70%);原患疾病以精神分裂症为主(54例,47.37%);口服给药引发的ADR更常见(103例次,90.35%);涉及的药品种类中,抗精神病药75例,占比最高(65.79%);累及器官/系统以消化系统最多(53例次,42.74%),奥氮平片致严重的ADR发生率最高(23例次,18.55%),主要临床表现均为肝功能异常;新的严重的ADR有8例(7.02%);大多数ADR经停药或采取治疗措施后可痊愈好转,无致死病例。结论:精神科药物在治疗精神疾病的同时可引发严重的ADR,其中奥氮平片致严重的ADR发生率最高,以消化系统症状为主。建议临床使用时应加强严重的ADR监测,促进临床安全用药。
ABSTRACT: OBJECTIVE: To investigate the characteristics of serious ADR in psychiatric hospital, and to provide reference for effective and safe use of drugs in the clinic. METHODS: 114 cases of serious ADR in our hospital from 2004 to 2015 were analyzed retrospectively in terms of general information, primary disease, route of administration, dosage form, drug types, organs or systems involved in ADR and clinical manifestations, top 5 ADR-inducing drugs and main clinical manifestations, etc. RESULTS: Of 114 serious ADR cases, the number of female was more than that of male(71/43). Patients aged 21-30 years old took up the greatest proprotion (35 cases, 30.70%). The main involved primary disease was schizophrenia (54 cases, 47.37%). Oral administration-induced ADR was most common (103 cases, 90.35%). The main involved drugs were antipsychotics, occupying the greatest proportion (75 cases, 65.79%). Digestive system involved was the most common (53 cases, 42.74%),  Olanzapine tablets had the highest incidence of serious ADR (23 cases, 18.55%), the main clinical manifestation were both abnormal liver function. There were 8 cases of new serious ADR (7.02%). Most of the ADR can be cured after drug withdrawal or countermeasures, no death case was found. CONCLUSIONS: Psychiatric drugs can induce serious ADR as treat psychiatric disease, among which the incidence of ADR induced by Olanzapine tablets is the highest and mainly manifestes digestive system symptoms. It is suggested to strengthen serious ADR monitoring to promote the safe use of drugs.
期刊: 2016年第27卷第35期
作者: 庄红艳,刘珊珊,郝红兵,果伟,马辛
AUTHORS: ZHUANG Hongyan,LIU Shanshan,HAO Hongbing,GUO Wei,MA Xin
关键字: 精神科药物;严重的;药品不良反应;分析与监测;合理用药
KEYWORDS: Psychiatric drugs;Serious;ADR; Analysis and monitoring; Rational drug use
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