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葛根素对老年女性骨质疏松性骨折人工髋关节置换术后股骨假体周围骨密度的影响
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| 篇名： | 葛根素对老年女性骨质疏松性骨折人工髋关节置换术后股骨假体周围骨密度的影响 |
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| 摘要： | 目的：探讨葛根素对老年女性骨质疏松性骨折人工髋关节置换术后股骨假体周围骨密度的影响。方法：将老年女性骨质疏松症并股骨颈骨折后行人工髋关节置换术的患者99例按随机数字表法分为对照组（49例）和试验组（50例）。术后对照组患者给予常规抗骨质疏松治疗：碳酸钙D3+阿仑膦酸钠+鲑鱼降钙素；试验组患者在对照组治疗基础上，加用葛根素注射液200～400 mg溶于葡萄糖注射液500 ml中静脉滴注，qd。20 d为1个疗程，两组患者均治疗2个疗程。观察并比较两组患者术后髋关节功能评分和股骨假体周围骨密度，以及不良反应发生情况。结果：对照组和试验组分别有3、2例患者脱落。术后18个月，试验组髋关节功能评分70～79分的患者明显少于对照组，试验组患者髋关节功能评分优良率明显高于对照组（89.58％ vs. 69.57％），差异均有统计学意义（P＜0.05）。术后15、18个月，试验组患者Gruen法分区R1～R5区的骨密度略高于对照组，但差异无统计学意义（P＞0.05）；R6～R7区的骨密度明显高于对照组，差异均有统计学意义（P＜0.05）。两组患者均无假体松动情况，均未见发热、皮疹、恶心、呕吐、头痛、头晕等不良反应发生。结论：在老年女性骨质疏松性骨折人工髋关节置换术后应用葛根素，可增强患者股骨假体周围的骨密度，且安全性较好。 |
| ABSTRACT： | OBJECTIVE： To investigate the effects of puerarin on bone mineral density around the femoral prosthesis of elderly women after osteoporotic fracture artificial hip joint replacement. METHODS： 99 elderly women after osteoporotic fracture artificial hip joint replacement were divided into control group （49 cases） and test group （50 cases） according to random number table. Control group received conventional treatment： calcium carbonate and vitamin D3+alendronate sodium+salmon calcitonin； test group was additionally given Puerarin injection 200-400 mg dissolved in Glucose injection 500 ml intravenously， qd， on the basis of control group. A treatment course lasted for 20 d， and both groups received 2 courses of treatment. The hip joint function score and bone mineral density around the femoral prosthesis of 2 groups were observed and compared after surgery， and the occurrence of ADR was also observed. RESULTS： 3 and 2 patients withdrew from control group and test group， respectively. 18 months after surgery， the patients with hip joint function score ranged 70-79 in test group was significantly less than in control group； the rate of excellent hip joint function score in test group was significantly higher than in control group， with statistical significance （P＜0.05）. 15 and 18 months after surgery， bone mineral density in R1-R5 range of Gruen range in test group was slightly higher than in control group， without statistical significance （P＞0.05）； bone mineral density in R6-R7 range was significantly higher than control group （89.58％ vs. 69.57％）， with statistical significance （P＜0.05）. The prosthesis loosening was not found in both groups， and ADR was also not found as fever， erythra， nausea， vomiting， headache， dizziness， etc. CONCLUSIONS： For the use of puerarin in elderly women after osteoporotic fracture artificial hip joint replacement， puerarin can increase the periprosthetic femur bone mineral density with good safety. |
| 期刊： | 2016年第27卷第35期 |
| 作者： | 孙玉敏，许晓琳，许金秀，刘秀丽，黄冬冬，程才 |
| AUTHORS： | SUN Yumin，XU Xiaolin，XU Jinxiu，LIU Xiuli，HUANG Dongdong，CHENG Cai |
| 关键字： | 葛根素；老年女性；骨质疏松性骨折；人工髋关节置换术；股骨假体；骨密度 |
| KEYWORDS： | Puerarin； Elderly women； Osteoporotic fracture； Artificial hip joint replacement； Periprosthetic femur； Bone mineral density |
| 阅读数： | 298 次 |
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