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普拉洛芬联合玻璃酸钠治疗中重度干眼症的临床观察
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| 篇名： | 普拉洛芬联合玻璃酸钠治疗中重度干眼症的临床观察 |
| TITLE： | |
| 摘要： | 目的：探讨普拉洛芬联合玻璃酸钠治疗中重度干眼症的有效性和安全性。方法：将180例中重度干眼症患者按随机数字表法分为观察组和对照组，各90例。对照组患者常规采用玻璃酸钠滴眼液，每次1滴，tid，同时采用清洁眼睑、热敷及睑板腺按摩等物理治疗；观察组患者在对照组治疗基础上加用普拉洛芬滴眼液，每次1滴，tid，2周为1个疗程。比较两组患者治疗前后的单眼角膜荧光素染色评分、泪膜破裂时间（BUT）、干眼症状评分、泪液分泌试验Ⅰ（SIT）结果，并据此评价两组患者的临床疗效；同时，观察两组患者的不良反应发生情况。 结果：治疗2、4周后，两组患者的单眼角膜荧光素染色评分、干眼症状评分均明显低于治疗前，BUT和SIT均明显长于治疗前，且治疗4周后各指标均明显优于治疗2周后；观察组患者治疗2、4周后各指标均明显优于同期对照组，差异均有统计学意义（P＜0.05）。观察组患者的有效率为94.44％，明显高于对照组的78.89％，差异有统计学意义（P＜0.05）。两组患者在用药过程中仅出现不同程度的眼部刺激症状，未出现其他严重的并发症，且眼部刺激症状评分各分数段组间比较，差异均无统计学意义（P＞0.05）。结论： 普拉洛芬联合玻璃酸钠治疗中重度干眼症患者，能明显控制眼表炎症、提高泪膜稳定性，疗效确切，且具有较高的安全性。 |
| ABSTRACT： | OBJECTIVE： To explore the effectiveness and safety of pranoprofen combined with sodium hyaluronate in the treatment of moderate and severe dry eyes. METHODS： 180 patients with moderate and severe dry eyes were divided into observation group and control group by random number table method， with 90 cases in each group. Control group was given Sodium hyaluronate eye drops， one drop each time， tid， and received physical therapy as cleaning eyelid， hot compress and glandulae tarsales massage. Observation group was additionally given Pranoprofen eye drops， one drop each time， tid. A treatment course lasted for 2 weeks. The monocular corneal fluorescence staining score， break-up time of tear film （BUT）， dry eye symptom scores， ShirmerⅠtest （SIT） before and after treatment， clinical efficacy and ADR were compared between 2 groups. RESULTS： 2， 4 weeks after treatment， monocular corneal fluorescence staining scores and dry eye symptom scores of 2 groups were significantly lower than before treatment； BUT and SIT were significantly longer than before； those indexes after 4 weeks of treatment were significantly better than after 2 weeks of treatment； those indexes of observation group after 2， 4 weeks of treatment were significantly better than those of control group at the same time， with statistical significance （P＜0.05）. The total effective rate of observation group was 94.44％， which was significantly higher than that of control group （78.89％）， with statistical significance （P＜0.05）. Both groups suffered from eye irritation symptom to different extent， and no other severe complications was found. There was no statistical significance in eye irritation symptom score between 2 groups （P＞0.05）. CONCLUSIONS： For moderate and severe dry eyes， pranoprofen combined with sodium hyaluronate can effectively control ocular inflammation and improve tear film stability. It shows definite therapeutic efficacy and good safety. |
| 期刊： | 2016年第27卷第35期 |
| 作者： | 赵仲平，郭翠玲，邵鸿展，任韩，何琼敏 |
| AUTHORS： | ZHAO Zhongping，GUO Cuiling，SHAO Hongzhan，REN Han，HE Qiongmin |
| 关键字： | 普拉洛芬；玻璃酸钠；中重度干眼症；炎症；单眼角膜荧光素染色评分；泪膜破裂时间；泪液分泌试验Ⅰ |
| KEYWORDS： | Pranoprofen； Sodium hyaluronate； Moderate and severe dry eyes； Inflammation； Monocular corneal fluorescence staining； BUT； SIT |
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