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乳酸菌联合氯喹那多-普罗雌烯阴道给药治疗萎缩性阴道炎高龄患者的临床观察
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| 篇名： | 乳酸菌联合氯喹那多-普罗雌烯阴道给药治疗萎缩性阴道炎高龄患者的临床观察 |
| TITLE： | |
| 摘要： | 目的： 探讨乳酸菌联合氯喹那多-普罗雌烯阴道给药治疗萎缩性阴道炎高龄患者的疗效及复发率。方法：选取萎缩性阴道炎高龄患者150例。按照随机数字表法分为A、B、C组，各50例。A组患者给予乳酸菌阴道胶囊2粒，qd（睡前）；B组患者给予氯喹那多-普罗雌烯阴道片1片，qd（睡前）；C组患者给予氯喹那多-普罗雌烯阴道片1片，qd（睡前），次日晨起给予乳酸菌阴道胶囊2粒，qd，均置入阴道深部。3组患者治疗时间均为18 d。观察3组患者临床疗效、阴道健康评分、阴道症状评分和阴道pH值，记录不良反应发生情况和随访期（12个月）复发率。结果：C组患者的临床总有效率（94.00％）明显高于A组（72.00％）和B组（74.00％），差异有统计学意义（P＜0.05）。治疗前，3组患者的阴道健康评分、阴道症状评分和阴道pH值比较，差异均无统计学意义（P＞0.05）。治疗后，3组患者的阴道健康评分均明显升高，阴道症状评分均明显降低，阴道pH值均明显降低，且C组患者上述指标改善程度明显优于A组和B组，差异均有统计学意义（P＜0.05）。3组患者治疗过程中均未见明显不良反应发生。C组患者的随访期复发率（4.00％）明显低于A组（18.00％）和B组（20.00％），差异均有统计学意义（P＜0.05）。结论：乳酸菌联合氯喹那多-普罗雌烯阴道给药治疗萎缩性阴道炎高龄患者，可有效缓解其临床症状和体征，提高阴道清洁度，调节局部pH值，降低复发风险，且安全性较高。 |
| ABSTRACT： | OBJECTIVE： To investigate therapeutic efficacy and recurrence rate of vaginal administration of lactobacillus combined with chlorquinaldol-promestriene for senile patients with atrophic vaginitis. METHODS： 150 senile patients with atrophic vaginitis were selected and divided into group A， B， C according to random number table， with 50 cases in each group. Group A was given Lactobacillus vaginal capsules， 2 capsules， qd （at bedtime）； group B given Chlorquinaldol-promestriene vaginal tablets， 1 tablet， qd （at bedtime）； group C given Chlorquinaldol-promestriene vaginal tablets， 1 tablet， qd （at bedtime）， and Lactobacillus vaginal capsules， 2 capsules， qd， next morning， implanting into vagina. 3 groups received treatment for 18 d. Clinical efficacy， vaginal health score， vaginal symptom score and vaginal pH value were observed in 3 groups， and the occurrence of ADR and recurrence rate during follow-up period （12 months） were recorded. RESULTS： The total effective rate of group C was 94.00％， which was significantly higher than group A （72.00％） and B （74.00％）， with statistical significance （P＜0.05）. Before treatment， there was no statistical significance in vaginal health score， vaginal symptom score and vaginal pH value among 3 groups （P＞0.05）. After treatment， vaginal health score of 3 groups were increased significantly， while vaginal symptom score and vaginal pH value were decreased significantly； and the improvement of above indexes in group C were significantly better than in group A and B， with statistical significance （P＜0.05）. No obvious ADR was found in 3 groups during treatment. The recurrence rate of group C during follow-up period （4.00％） was significantly lower than that of group A （18.00％） and group B （20.00％）， with statistical significance （P＜0.05）. CONCLUSIONS： Vaginal administration of lactobacillus combined with chlorquinaldol-promestriene for senile patients with atrophic vaginitis can effectively relieve clinical symptoms and signs， improve vaginal cleanliness， regulate the local pH value and reduce the risk of recurrence， with good safety. |
| 期刊： | 2016年第27卷第35期 |
| 作者： | 吉冬梅，吴虹 |
| AUTHORS： | JI Dongmei，WU Hong |
| 关键字： | 乳酸菌；氯喹那多-普罗雌烯；萎缩性阴道炎；高龄；阴道给药；疗效；复发 |
| KEYWORDS： | Lactobacillus； Chlorquinaldol-promestriene； Atrophic vaginitis； Senile； Vaginal administration； Therapeutic efficacy； Recurrence |
| 阅读数： | 1136 次 |
| 本月下载数： | 3 次 |
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