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阿魏酸哌嗪联合谷胱甘肽治疗糖尿病肾病的临床观察
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| 篇名： | 阿魏酸哌嗪联合谷胱甘肽治疗糖尿病肾病的临床观察 |
| TITLE： | |
| 摘要： | 目的：观察阿魏酸哌嗪联合谷胱甘肽治疗糖尿病肾病的临床疗效及安全性。方法：选取在我院确诊并治疗的糖尿病肾病患者80例，按随机数字表法分为观察组和对照组，各40例。两组患者均予以控制血糖、血脂、血压等一般治疗，对照组患者在一般治疗的基础上加服谷胱甘肽片，每次400 mg，tid；观察组患者在对照组的基础上加服阿魏酸哌嗪片，每次100 mg，tid。两组患者均治疗12周。检测两组患者治疗前后空腹血糖（FPG）、餐后2 h血糖（2 hPG）、血压、血脂、血肌酐（Scr）、血尿素氮（BUN）、24 h尿总蛋白及尿白蛋白、尿β2微球蛋白（β2-MG）、尿N-乙酰-β-氨基葡萄糖苷酶（NAG）等指标，并观察不良反应发生情况。结果：治疗前，两组患者FPG、2 hPG、血压、血脂、Scr、BUN、24 h尿总蛋白及尿白蛋白、尿β2-MG、尿NAG等指标比较，差异均无统计学意义（P＞0.05）；治疗后，两组患者上述指标均显著改善，且观察组显著优于对照组，差异均有统计学意义（P＜0.05）。两组患者均未见明显不良反应发生。结论：阿魏酸哌嗪联合谷胱甘肽能明显改善糖尿病肾病患者血糖、血压、血脂水平及肾功能，且安全性较好。 |
| ABSTRACT： | OBJECTIVE： To observe the clinical efficacy and safety of piperazine ferulate combined with glutathione in the treatment of diabetic nephropathy. METHODS： 80 patients with diabetic nephropathy in our hospital were divided into observation group and control group according to random number table， with 40 cases in each group. Both groups was given general treatment as blood glucose， blood lipid and blood pressure control. Control group was additionally given Reduced glutathione tablets 400 mg， tid， on the basis of general treatment. Observation group was additionally given Piperazine ferulate tablets 100 mg， tid， on the basis of control group. Both groups were treated for 12 weeks. The fasting plasma glucose （FPG），2 h postprandial plasma glucose （2 hPG），blood pressure， blood lipid， serum creatinine （Scr），blood urea nitrogen （BUN），24 h urinary total protein and albumin， urine β2 microglobulin （β2-MG） and N-acetyl-β-glucosaminidase （NAG） of 2 groups were detected before and after treatment. The occurrence of ADR was observed. RESULTS： Before treatment， there was no statistical significance in FPG， 2 hPG， blood pressure， blood lipid， Scr， BUN， 24 h urinary total protein and albumin， urine β2-MG and NAG between 2 groups （P＞0.05）. After treatment， above indexes of 2 groups were improved significantly， and the observation group was better than the control group， with statistical significance （P＜0.05）. No obvious ADR was found in 2 groups. CONCLUSIONS： In the treatment of diabetic nephropathy， piperazine ferulate combined with glutathione can improve blood glucose， blood pressure， blood lipid levels and renal function with good safety. |
| 期刊： | 2016年第27卷第35期 |
| 作者： | 龙敏，程伟，王波，刘东方 |
| AUTHORS： | LONG Min，CHENG Wei，WANG Bo，LIU Dongfang |
| 关键字： | 阿魏酸哌嗪；谷胱甘肽；糖尿病肾病；血糖；血压；血脂；肾功能 |
| KEYWORDS： | Piperazine ferulat； Glutathione； diabetic nephropathy； Blood glucose； Blood pressure； Blood lipid； Renal function |
| 阅读数： | 443 次 |
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