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盐酸舍曲林联合埃索美拉唑治疗胃食管反流病伴抑郁患者的临床观察
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| 篇名： | 盐酸舍曲林联合埃索美拉唑治疗胃食管反流病伴抑郁患者的临床观察 |
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| 摘要： | 目的：观察盐酸舍曲林联合埃索美拉唑治疗胃食管反流病伴抑郁患者的临床疗效及安全性。方法：选取在我院诊治的胃食管反流病伴抑郁患者80例，按随机数字表法分为对照组和观察组，各40例。对照组患者口服埃索美拉唑镁肠溶片，每次40 mg，qd；观察组患者在对照组基础上加服盐酸舍曲林片，每次50 mg，qd。两组患者均治疗1个月。观察两组患者临床疗效及治疗前后临床症状积分、胃食管反流病诊断问卷（GERD Q量表）评分和抑郁自评量表（SDS）评分，并比较不良反应发生情况。结果：观察组患者总有效率为92.50％，显著高于对照组的77.50％，差异有统计学意义（P＜0.05）。治疗前，两组患者临床症状积分、GERD Q量表评分和SDS评分比较，差异均无统计学意义（P＞0.05）；治疗后，两组患者上述评分均显著改善，且观察组显著优于对照组，差异均有统计学意义（P＜0.05）。两组患者不良反应发生率比较，差异无统计学意义（P＞0.05）。结论：盐酸舍曲林联合埃索美拉唑治疗胃食管反流病伴抑郁患者的疗效显著，能有效缓解其临床症状，改善抑郁状态，且安全性较好。 |
| ABSTRACT： | OBJECTIVE： To observe clinical efficacy and safety of sertraline hydrochloride combined with esomeprazole in the treatment of patients with gastroesophageal reflux disease complicating with depression. METHODS： 80 patients with gastroesophageal reflux disease complicating with depression selected from our hospital were divided into control group and observation group according to random number table， with 40 cases in each group. Control group received Esomeprazole magnesium enteric-coated tablets orally 40 mg， qd； observation was additionally given Sertraline hydrochloride tablets 50 mg， qd， on the basis of control group. Both groups received treatment for 1 month. Clinical efficacies of 2 groups were observed as well as clinical symptom score， gastroesophageal reflux disease diagnostic questionnaire （GERD Q scale） score， SDS score. The occurrence of ADR was compared between 2 groups. RESULTS： The total effective rate of observation group 92.50％， which was significantly higher than 77.50％ of control group， with statistical significance （P＜0.05）. Before treatment， there was no statistical significance in clinical symptom score， GERD Q scale score and SDS score （P＞0.05）. After treatment， above scores of 2 groups were improved significantly， and the observation group was significantly better than the control group， with statistical significance （P＜0.05）. There was no statistical significance in the incidence of ADR between 2 groups （P＞0.05）. CONCLUSIONS： Sertraline hydrochloride combined with esomeprazole shows significantly therapeutic efficacy in the treatment of patients with gastroesophageal reflux disease complicating with depression， and can effectively alleviate the clinical symptoms and improve depression with good safety. |
| 期刊： | 2016年第27卷第35期 |
| 作者： | 马卉，黄业斌，尚晓辉 |
| AUTHORS： | MA Hui，HUANG Yebin，SHANG Xiaohui |
| 关键字： | 盐酸舍曲林；埃索美拉唑；胃食管反流病；抑郁；疗效 |
| KEYWORDS： | Sertraline hydrochloride； Esomeprazole； Gastroesophageal reflux disease； Depression； Efficacy |
| 阅读数： | 861 次 |
| 本月下载数： | 8 次 |
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