安宫牛黄丸辅助治疗缺血性中风急性期疗效的Meta分析
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篇名: | 安宫牛黄丸辅助治疗缺血性中风急性期疗效的Meta分析 |
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摘要: | 目的:系统评价安宫牛黄丸辅助治疗缺血性中风急性期的疗效,为临床提供循证参考。方法:计算机检索中国期刊全文数据库、中文科技期刊数据库、万方数据库、PubMed和Cochrane图书馆,收集安宫牛黄丸联合西医常规治疗(试验组)对比单纯西医常规治疗(对照组)用于缺血性中风急性期的随机对照试验(RCT)或半随机对照试验(qRCT),提取资料并采用Cochrane偏倚风险评估工具进行质量评价后,采用Rev Man 5.3统计软件进行Meta分析。结果:共纳入6项RCT、3项qRCT,合计620例患者。Meta分析结果显示,试验组患者有效率显著高于对照组[OR=4.28,95%CI(2.62,6.98),P<0.001],美国国立卫生研究院卒中量表(NIHSS)评分显著低于对照组[SMD=-0.75,95%CI(-0.95,-0.56),P<0.001],差异均有统计学意义。结论:安宫牛黄丸辅助治疗缺血性中风急性期疗效较好,可以显著改善患者的神经功能缺损程度。 |
ABSTRACT: | OBJECTIVE: To systematically review the clinical efficacy of Angong niuhuang pill in the adjuvant treatment of ischemic stroke in acute phase,and provide evidence-based reference for clinic. METHODS: Retrieved from CJFD, VIP, Wanfang Database, PubMed and the Cochrane Library, randomized controlled trails (RCT) or quasi-random control trials (qRCT) about Angong niuhuang pill combined with Western medicine (test group) versus Western medicine alone (control group) in the treatment of ischemic stroke in acute phase were collected. Meta-analysis was performed by using Rev Man 5.3 software after data extraction and quality evaluation by Cochrane risk of bias tool. RESULTS: Totally 6 RCT and 3 qRCT were included, involving 620 patients. Results of Meta-analysis showed, the effective rate in test group was significantly higher than control group [OR=4.28, 95%CI(2.62,6.98),P<0.001], NIHSS score was significantly lower than control group [SMD=-0.75,95%CI(-0.95,-0.56),P<0.001], with statistical significances. CONCLUSIONS: Angong niuhuang pill shows good efficacy in the adjuvant treatment of ischemic stroke in acute phase, it can significantly improve the NIHSS degree. |
期刊: | 2016年第27卷第36期 |
作者: | 侯敏,王显凤,陈剑鸿 |
AUTHORS: | HOU Min,WANG Xianfeng,CHEN Jianhong |
关键字: | 安宫牛黄丸;缺血性中风急性期;Meta分析;疗效 |
KEYWORDS: | Angong niuhuang pill; Ischemic stroke in acute phase; Meta-analysis; Efficacy |
阅读数: | 346 次 |
本月下载数: | 1 次 |
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