奥硝唑联合阿奇霉素治疗盆腔炎的系统评价
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篇名: | 奥硝唑联合阿奇霉素治疗盆腔炎的系统评价 |
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摘要: | 目的:系统评价奥硝唑联合阿奇霉素治疗盆腔炎的疗效,为临床提供循证参考。方法:计算机检索Cochrane 图书馆、PubMed、EMBase、SCI、中国期刊全文数据库、中文科技期刊数据库、中国生物医学文献数据库和万方数据库,收集奥硝唑联合阿奇霉素(试验组)对比甲硝唑单用或联合其他抗菌药物(对照组)治疗盆腔炎的随机对照试验(RCT),提取资料并参考“Cochrane系统评价员手册5.3”进行文献质量评价,采用Rev Man 5.3统计软件进行Meta分析。结果:共纳入6项RCT,合计658例患者。Meta分析结果显示,试验组患者总有效率[RR=1.21,95%CI(1.14,1.29),P<0.001]和治愈率[RR=1.52,95%CI(1.32,1.76),P<0.001]均显著高于对照组,差异均有统计学意义。结论:奥硝唑联合阿奇霉素治疗盆腔炎疗效较好。 |
ABSTRACT: | OBJECTIVE: To systematically review the efficacy and safety of ornidazole combined with azithromycin in the treatment of pelvic inflammatory disease (PID), and provide evidence-based reference for clinic. METHODS: Retrieved from Cochrane Library,PubMed,EMBase,SCI,CJFD,VIP,CBM and Wanfang Database, randomized controlled trials (RCT) about ornidazole combined with azithromycin (test group) versus ornidazole alone or combined with other antibiotics (control group) in the treatment of PID were collected. Analysis was performed by using Rev Man 5.3 software after data extraction and quality evaluation of literature by referring to the Cochrane Review Manual 5.3. RESULTS: Totally 6 RCTs were involved, including 658 patients. Results of Meta-analysis showed the total effective rate [RR=1.21,95%CI(1.14,1.29),P<0.001] and cure rate [RR=1.52,95%CI(1.32,1.76),P<0.001] in test group were significantly higher than control group, with statistical significances. CONCLUSIONS: The efficacy of ornidazole combined with azithromycin is obviously superior to ornidazole alone in the treatment of PID, with similar safety. |
期刊: | 2016年第27卷第36期 |
作者: | 陶婉君,李根,龙旭,张澜霖 |
AUTHORS: | TAO Wanjun,LI Gen,LONG Xu,ZHANG Lanlin |
关键字: | 奥硝唑;阿奇霉素;盆腔炎;Meta分析 |
KEYWORDS: | Ornidazole; Azithromycin; Pelvic inflammatory disease; Meta-analysis |
阅读数: | 563 次 |
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