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基于改良德尔菲法的《治疗药物监测管理指南》研究问题体系构建
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| 篇名： | 基于改良德尔菲法的《治疗药物监测管理指南》研究问题体系构建 |
| TITLE： | Construction of the research question system of the Guideline for the Management of Therapeutic Drug Monitoring based on modified Delphi method |
| 摘要： | 目的 构建《治疗药物监测管理指南》（以下简称《指南》）的研究问题体系，为《指南》的制定提供依据。方法在文献研究和专家访谈的基础上，初步构建《指南》研究问题调查问卷，通过改良德尔菲法对《指南》制定专家进行线上问卷调研并召开专家共识会议，确定《指南》研究问题体系。结果共发放调研问卷59份，回收有效问卷52份，专家积极系数为88.14%。纳入专家来自21个省/自治区/直辖市，涵盖治疗药物监测相关多学科专家，均具有高级专业技术职称。调研专家经过一轮调研即对研究问题达成共识，形成了涵盖治疗药物监测开展指征（4个一级研究问题、10个二级研究问题、31个三级研究问题）、治疗药物监测技术流程（3个一级研究问题、9个二级研究问题、13个三级研究问题）、结果解读及临床应用（3个一级研究问题、3个二级研究问题）、质量控制（8个一级研究问题、12个二级研究问题）4个板块的研究问题体系。4个板块的重要性评分为4.71～4.88分，满分率均不低于73.08%，专家权威系数均不低于0.90，重要性评分变异系数均不高于0.11，肯德尔协调系数W为0.464～0.626（P均小于0.05）。结论构建的研究问题体系具有较高的权威性、科学性和可靠性，可为《指南》标准化制定奠定基础。 |
| ABSTRACT： | OBJECTIVE To construct a research question system of the Guideline for the Management of Therapeutic Drug Monitoring （hereinafter referred to as the Guideline ）， so as to provide the basis for the formulation of the Guideline . METHODS Based on literature research and expert interviews， the questionnaire about research questions of the Guideline was initially constructed. Through the modified Delphi method， the online questionnaire survey and expert consensus meeting were conducted among the Guideline development experts to determine the research question system of the Guideline . RESULTS A total of 59 questionnaires were distributed， and 52 valid questionnaires were collected. The positive coefficient of experts was 88.14%. The experts came from 21 provinces/autonomous regions/municipalities directly under the central government， covering multidisciplinary experts related to therapeutic drug monitoring， all of whom held senior professional titles. After one round of survey， a consensus was reached on the research questions， and a research question framework encompassing four research parts was constructed， including： indications for conducting therapeutic drug monitoring （4 first-level research questions，10 second-level research questions， 31 third-level research questions）； therapeutic drug monitoring technical process （3 first-level research questions， 9 second-level research questions， 13 third-level research questions）； result interpretation and clinical application （3 first-level research questions and 3 second-level research questions）； quality control （8 first-level research questions and 12 second-level research questions）. The importance scores for the four parts ranged from 4.71 to 4.88， with full-score rates all no less than 73.08%. The expert authori ty coefficients were all no less than 0.90， the coefficients of variation of importance scores were all no higher than 0.11， and Kendall’s W ranged from 0.464 to 0.626 （all P ＜0.05）. CONCLUSIONS The constructed research question system has high authority， scientificity， and reliability， laying a foundation for the standardized formulation of the Guideline . |
| 期刊： | 2026年第37卷第10期 |
| 作者： | 段蓉；缪丽燕；李正翔 |
| AUTHORS： | DUAN Rong，MIAO Liyan，LI Zhengxiang |
| 关键字： | 治疗药物监测；研究问题；体系构建；管理指南；改良德尔菲法 |
| KEYWORDS： | therapeutic drug monitoring； research questions； |
| 阅读数： | 1 次 |
| 本月下载数： | 0 次 |
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