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拉考沙胺群体药动学研究的系统分析
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| 篇名： | 拉考沙胺群体药动学研究的系统分析 |
| TITLE： | Systematic analysis of population pharmacokinetics of lacosamide |
| 摘要： | 目的 系统分析拉考沙胺的群体药动学（PPK）研究，并阐述其在不同人群中的药动学影响因素。方法检索WebofScience、PubMed、Embase、迈特思创、中国知网、万方数据和维普网等中英文数据库，收集拉考沙胺PPK相关研究，提取相关资料，并使用预测模型偏倚风险评估工具对纳入研究进行PPK模型质量评价。结果最终纳入的8项研究中，6项为回顾性研究，2项为前瞻性研究；5项纳入了儿童患者；7项采用一室模型，1项采用两室模型；4项的模型质量为A级，各有2项的模型质量分别为B、C级。体重、肾功能及肝药酶诱导剂是影响拉考沙胺PPK的显著协变量。结论现有拉考沙胺PPK研究以儿童人群为主，药动学变异主要受体重、肾功能及肝药酶诱导剂影响。但当前PPK研究普遍缺乏外部验证，模型的普适性有待确证。 |
| ABSTRACT： | OBJECTIVE To systematically analyze the population pharmacokinetics （PPK） studies of lacosamide and expound the influential factors of its pharmacokinetics in different populations. METHODS PPK studies of lacosamide were collected by searching the databases， such as Web of Science， PubMed， Embase， Metasearch， CNKI， Wanfang Data and VIP， both in Chinese and English. Relevant data were extracted， and the Prediction Model Risk of Bias Assessment Tool was used to evaluate the quality of the PPK models in the included studies. RESULTS Among 8 studies ultimately included， 6 were retrospective studies and 2 were prospective studies； 5 studies involved pediatric patients. Seven studies adopted a one-compartment model， while 1 study utilized a two-compartment model. Four studies had a model quality rating of grade A， two of grade B and two of grade C， respectively. Body weight， renal function， and hepatic enzyme inducers were significant covariates influencing PPK of lacosamide. CONCLUSIONS The existing PPK studies of lacosamide are predominantly conducted in pediatric populations. Pharmacokinetic variability is mainly influenced by body weight， renal function， and hepatic enzyme inducers. However， most PPK studies have not conducted external validation， and the generalizability of the models remains to be confirmed. |
| 期刊： | 2026年第37卷第10期 |
| 作者： | 崔赛；孟楠；吴惠珍；吴茵 |
| AUTHORS： | CUI Sai，MENG Nan，WU Huizhen，WU Yin |
| 关键字： | 拉考沙胺；群体药动学；个体化给药；影响因素；系统分析 |
| KEYWORDS： | lacosamide； population pharmacokinetics； individualized administration； influential factors； systematic analysis |
| 阅读数： | 1 次 |
| 本月下载数： | 0 次 |
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