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基于“态靶辨治”理论构建补肾活血汤分期化裁联合HRT治疗早发性卵巢功能不全的用药策略
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| 篇名： | 基于“态靶辨治”理论构建补肾活血汤分期化裁联合HRT治疗早发性卵巢功能不全的用药策略 |
| TITLE： | Construction of a medication strategy integrating staged modifications of Bushen huoxue decoction with HRT for premature ovarian insufficiency based on the “state-target differentiation and treatment”theory |
| 摘要： | 目的 探讨补肾活血汤分期化裁联合激素补充疗法（HRT）治疗早发性卵巢功能不全（POI）的协同用药策略。方法梳理仝小林院士“态靶辨治”理论内涵及POI的疾病分期特征，划分POI隐匿期、亚临床期、临床期、衰竭期对应的核心病机“态”与关键客观指标“靶”，以补肾活血汤为基本方，分析其分期化裁方案及其与HRT的时序组合。结果与结论将POI四期分别对应肾阴亏虚、肾虚血瘀、心肾不交、阴阳两虚4种“态”，以促卵泡激素（FSH）、抗米勒管激素（AMH）、窦卵泡计数（AFC）、Kupperman评分等作为分期评估“标靶”，结合各期“态-靶”特征，确立了以补肾活血汤为基础，辨证化裁、随期调整的用药思路：隐匿期以中药治疗为主，亚临床期采用序贯协同方案，临床期以激素补充疗法为主、中药治疗为辅，衰竭期则采用中西医结合来巩固根本。 |
| ABSTRACT： | OBJECTIVE To explore a synergistic medication strategy integrating stage-specific modifications of Bushen huoxue decoction with hormone replacement therapy （HRT） for premature ovarian insufficiency （POI）. METHODS The connotation of Academician Tong Xiaolin’s “state-target differentiation and treatment” theory and the disease stage characteristics of POI were summarized. The latent stage， subclinical stage， clinical stage and exhaustion stage of POI were classified into corresponding core pathogenesis “states” and key objective indicator “targets”. Taking Bushen huoxue decoction as the basic prescription， its staged modification scheme and its sequential combination with HRT were analyzed. RESULTS & CONCLUSIONS The four stages of POI correspond to four pathogenic states respectively： kidney yin deficiency， kidney deficiency and blood stasis， heart-kidney disharmony， and deficiency of both yin and yang. Follicle-stimulating hormone （FSH）， anti-Müllerian hormone （AMH）， antral follicle count （AFC） and Kupperman score were taken as the evaluation targets of staging. Combined with the “state-target” characteristics of each stage， a medication principle based on Bushen huoxue decoction with syndrome differentiation modification and stage-adjusted administration was established： traditional Chinese medicine dominates in the latent stage， a sequential collaborative regimen is adopted in the subclinical stage， HRT is dominant supplemented by traditional Chinese medicine in the clinical stage， and integrated traditional Chinese and Western medicine is applied to consolidate the root cause in the exhaustion stage. |
| 期刊： | 2026年第37卷第10期 |
| 作者： | 王伶俐；陈秋薇；肖汐；褚烔；陈玥；陈思 |
| AUTHORS： | WANG Lingli，CHEN Qiuwei，XIAO Xi，CHU Tong，CHEN Yue，CHEN Si |
| 关键字： | 态靶辨治；早发性卵巢功能不全；补肾活血汤；激素补充疗法；用药策略 |
| KEYWORDS： | state-target differentiation and treatment； premature ovarian insufficiency； Bushen huoxue decoction； hormone |
| 阅读数： | 3 次 |
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