基于保护动机理论的抗凝患者用药依从性风险筛查量表的构建与验证
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篇名: 基于保护动机理论的抗凝患者用药依从性风险筛查量表的构建与验证
TITLE: Construction and validation of a medication adherence risk screening scale for patients on anticoagulant therapy based on protection motivation theory
摘要: 目的 编制抗凝患者用药依从性风险筛查量表并检验其信效度,为临床识别抗凝治疗依从风险及实施个体化干预提供测评工具。方法以保护动机理论为框架,通过文献分析、半结构化访谈、专家函询和预调查形成包含20个条目的预试量表;采用便利抽样法对多地医疗机构抗凝治疗患者发放问卷。经项目分析筛选条目,采用探索性因子分析(EFA)、验证性因子分析(CFA)检验结构效度并进一步筛选条目,以新版一般自我效能量表简表(NGSES-SF)检验效标关联效度,并评价量表的内部一致性与分半信度。结果共发放问卷425份,回收有效问卷411份,有效回收率为96.71%。经项目分析和EFA分析,最终正式量表包括感知严重性、感知易感性、反应效能和自我效能4个维度,共11个条目。EFA提取4个公因子,累计方差贡献率为68.805%。CFA显示,χ2自由度比为1.839,近似误差均方根为0.064,拟合优度指数为0.945,比较拟合指数为0.979,Tucker-Lewis指数为0.969。量表总分及各维度得分与效标量表NGSES-SF总分均呈显著正相关(P<0.05),其中量表总分与NGSES-SF总分的相关系数为0.346。量表的内部一致性克朗巴赫系数为0.878,分半信度系数为0.743。结论本研究构建的抗凝患者用药依从性风险筛查量表信效度良好,可用于筛查抗凝患者的用药依从性风险,并可作为临床开展分层靶向干预的测评工具。
ABSTRACT: OBJECTIVE To develop a risk screening scale for medication adherence in anticoagulated patients and evaluate its reliability and validity, thereby providing an assessment tool for identifying medication adherence risks during anticoagulant therapy and implementing individualized interventions.METHODS Based on the protection motivation theory, a preliminary scale containing 20 items was developed through literature analysis, semi-structured interviews, expert consultation and a pilot survey. Convenience sampling was used to distribute questionnaires to patients receiving anticoagulant therapy at multiple medical institutions. Item analysis was conducted to select items. Exploratory factor analysis (EFA) and confirmatory factor analysis (CFA) were used to assess construct validity and further screen items. The New General Self-Efficacy Scale-Short Form (NGSES-SF) was used to assess criterion-related validity, and the internal consistency and split-half reliability of the scale were evaluated.RESULTS A total of 425 questionnaires were distributed, and 411 valid questionnaires were recovered, yielding an effective recovery rate of 96.71%. The final scale consisted of four dimensions:perceived severity, perceived susceptibility, response efficacy and self-efficacy, with a total of 11 items. EFA extracted four common factors, with a cumulative variance contribution rate of 68.805%. CFA showed the Chi-square degrees of freedom ratio was 1.839, the root mean square error of approximation was 0.064, the goodness-of-fit index was 0.945, the comparative fit index was 0.979, and the Tucker-Lewis index was 0.969. The total score of the scale and the scores of each dimension were significantly positively correlated with the scores of the criterion scale NGSES-SF ( P <0.05), and the correlation coefficient between the total score of the scale and the total score of NGSES-SF was 0.346. The Cronbach’s α coefficient for internal consistency was 0.878, and the split-half reliability coefficient was 0.743.CONCLUSIONS The medication adherence risk screening scale for patients on anticoagulant therapy constructed in this study demonstrated good reliability and validity, which can be used to screen for medication adherence risk in patients on anticoagulant therapy, and serve as an assessment tool for stratified targeted interventions in clinical practice.
期刊: 2026年第37卷第20期
作者: 林卓苗;许欣;韩冰;谢文龙;董淑杰
AUTHORS: LIN Zhuomiao,XU Xin,HAN Bing,XIE Wenlong,DONG Shujie
关键字: 抗凝;用药依从性;保护动机理论;风险筛查;量表;信度;效度
KEYWORDS: Anticoagulation;Medication adherence;protection motivation theory;risk screening;Scale;Reliability;Validity
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