我国精准医学概念的循证研究
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篇名: 我国精准医学概念的循证研究
TITLE:
摘要: 目的:了解我国精准医学的概念及内容,为我国精准医学的发展提供参考。方法:采用循证评价方法,以“精准医学”“精准医疗”“precision medicine”为检索词检索中国生物医学文献数据库、中国知网、万方数据库、中文科技期刊数据库、PubMed和Ovid EMBase数据库截至2015年11月17日的所有文献,提取研究者(第一作者或通信作者单位隶属于我国)、研究内容和精准医学概念等相关信息,汇总和分析基于我国国情的精准医学概念及内容,并比较精准医学和个体化医学的异同。结果:共纳入相关文献54篇,大多发表于2015年(51篇),且主要来自于医院(28篇)和高校(14篇);以概念介绍的文献最多(23篇),其次为疾病精准诊疗(19篇)和精准医学相关技术(7篇);共39篇文献给出了精准医学的具体概念。除美国精准医学强调的遗传学信息外,我国精准医学还包括了疾病诊断、治疗相关技术以及临床应用等内容。个体化医学与精准医学概念存在重叠,但后者强调疾病的分类诊断,更具可操作性。结论:我国精准医学的广义概念是基于患者个体遗传学信息,综合各种疾病诊疗技术和影响因素,进行疾病精准分类和诊断,以实现个性化精准干预的学科,具有重点关注、全面发展的特点。
ABSTRACT: OBJECTIVE:To investigate the concepts and contents of the Chinese precision medicine, and to provide reference for the development of precision medicine in China. METHODS:By evidence-based evaluation method, using “jingzhun yixue”“jingzhun yiliao”“precision medicine”as keywords, all literatures were retrieved from CBM, CNKI, Wanfang, VIP, PubMed and Ovid EMBase databases up to Nov. 17th, 2015. The relevant information were extracted, including researchers (first author or correspondence author’s unit belonged to China), domains and concepts. The concepts and contents of the Chinese precision medicine based on China’s national condition were summarized and analyzed, and the difference between precision medicine and personalized medicine was compared. RESULTS:54 studies were included, the results indicated most studies (51 literatures) were published in 2015 by hospitals (28 literatures) and high schools (14 literatures); most literatures (23 literatures) presented the concept of precision medicine, followed by disease precision medicine (19 literatures) and relevant technology of precision medicine (7 literatures); a total of 39 literatures presented the specific concept of precision medicine. Besides genetic information involved in American precision medicine, the Chinese one expanded the disease diagnosis and treatment technology, as well as the application. Personalized medicine and precision medicine were in common partially, however, the latter one underlined the disease classification and diagnosis, which was more practicable. CONCLUSIONS:Chinese precision medicine involves disease diagnosis and treatment technology as well as influential factors based on genetic information, and includes disease classification and diagnosis so as to perform personalized precision intervention. The Chinese precision medicine is overall developed and focused.
期刊: 2017年第28卷第8期
作者: 吴斌,占美,徐珽,胡巧芝,田方圆
AUTHORS: WU Bin,ZHAN Mei,XU Ting,HU Qiaozhi,TIAN Fangyuan
关键字: 精准医学;概念;个体化医学;循证医学
KEYWORDS: Precision medicine; Concept; Personalized medicine; Evidence-based medicine
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