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普乐士泰胶囊对慢性非细菌性前列腺炎模型大鼠的改善作用
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| 篇名： | 普乐士泰胶囊对慢性非细菌性前列腺炎模型大鼠的改善作用 |
| TITLE： | |
| 摘要： | 目的：考察普乐士泰胶囊对慢性非细菌性前列腺炎（CNP）模型大鼠的改善作用。方法：将60只大鼠随机分为假手术组（蒸馏水）、模型组（蒸馏水）、普乐安片组（阳性对照，2 g/kg）和普乐士泰胶囊高、中、低剂量组（16、8、4 g/kg），除假手术组外的其余5组大鼠均注射消痔灵注射液0.2 mL复制 CNP模型。造模7 d后ig相应药物，每日1次，连续45 d。末次给药后24 h，肉眼观察前列腺的病变并称定其湿质量；显微镜下进行白细胞（WBC）计数和卵磷脂小体（SPL）计数， 并对前列腺组织切片进行病理观察。结果：与假手术组比较，模型组大鼠前列腺局部出现灰白色结节、腺体与周围组织发生粘连等病变；腺体湿质量和前列腺组织中WBC、SPL计数均显著增加（P＜0.01）；显微镜下可见前列腺间质中有明显充血、水肿及多种炎症细胞浸润。与模型组比较，普乐安片组和普乐士泰胶囊各剂量组大鼠前列腺局部灰白色结节减少、腺体与周围组织粘连程度减轻；腺体湿质量和前列腺组织中WBC、SPL计数均显著减少（P＜0.01）；显微镜下可见病理变化得到不同程度改善，且以普乐士泰胶囊高剂量组改善最为明显，前列腺组织间质中仅有轻度充血、水肿和少量炎症细胞浸润。结论：普乐士泰胶囊对CNP模型大鼠有一定的改善作用。 |
| ABSTRACT： | OBJECTIVE： To investigate the improvement effect of Prostatitis capsule on chronic non-bacterial prostatitis （CNP） model rats. METHODS： 60 rats were randomly divided into sham operation group （distilled water）， model group （distilled water）， Pule’an tablet group （positive control， 2 g/kg） and Prostatitis capsule high-dose， medium-dose， low-dose groups （16， 8， 4 g/kg）. Except for sham operation group， other 5 groups were injected Xiaozhiling injection 0.2 mL to reduce CNP model. After 7 d of modeling， they received related medicines， ig， once a day， for 45 d. After 24 h of last administration， prostate lesions were observed by eyes and wet quality was weighed. White blood cell （WBC） count and lecithin body （SPL） count were conducted under microscope， and prostate tissue slices were pathologically observed. RESULTS： Compared with sham operation group， prostate showed gray nodules， adhesion in glands and surrounding tissue； wet quality of prostate and WBC， SPL count in prostate tissue were significantly increased （P＜0.01）； under microscope， there were significant congestion， edema and a variety of inflammatory cell infiltration in prostate interstitial. Compared with model group， gray nodules in prostate in Pule’an tablet group and Prostatitis capsule group were reduced， as well as adhesion degree in prostate and surrounding tissue； wet quality of prostate and WBC， SPL count in prostate tissue were significantly decreased （P＜0.01）； pathological changes had improved to varying degrees under microscope， especially the changes in Prostatitis capsule high-dose group， and prostate tissue only showed mild congestion， edema and little inflammatory cell infiltration. CONCLUSIONS： Prostatitis capsule has a certain improvement effect on CNP model rats. |
| 期刊： | 2017年第28卷第22期 |
| 作者： | 叶绿萍，李德钢，刘素春，马儒清，宾彬 |
| AUTHORS： | YE Lüping，LI Degang，LIU Suchun，MA Ruqing，BIN Bin |
| 关键字： | 普乐士泰胶囊；慢性非细菌性前列腺炎；白细胞；卵磷脂小体；大鼠 |
| KEYWORDS： | Prostatitis capsule； Chronic non-bacterial prostatitis； Leukocytes； Lecithin body； Rats |
| 阅读数： | 658 次 |
| 本月下载数： | 6 次 |
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